Glasgow signing Jess Fishlock finished off a fine day for City in Aberdeen, scoring the final goal in a 4-0 win over the Dons.
Ruesha Littlejohn opened the scoring in the eighth minute and a Sarah Crilly strike saw City double their lead before the break.
Littlejohn added a third before Fishlock netted a goal on her Glasgow debut to keep Eddie Wolecki-Black's side clear at the top of the table.
Spartans moved up to third place after an impressive 3-2 win over Hibernian, courtesy of a Lana Clelland double and a strike from Kerry Montgomery.
Celtic leapfrogged Aberdeen into fifth place following a 4-1 win away to Rangers.
Julie Fleeting's double was added to by Carla Jackson, before a fine strike from youngster Abigail Harrison sealed the win and cancelled out the opener from Rangers full-back Karen Penglase.
Falkirk remain rooted to the bottom of the table after going down 3-1 to Forfar.
Buchan won for the second consecutive week, picking up three points against Kilwinning following a 5-1 win and Hamilton Accies remain within touching distance of Forfar in in eighth place, after beating Hutchison Vale 2-0.
Aberdeen 0-4 Glasgow City
Rangers 1-4 Celtic
Spartans 3-2 Hibs
Hutchison Vale 0-2 Hamilton Accies
Buchan 5-1 Kilwinning
Falkirk 1-3 Forfar Farmington