Ludogorets produced the surprise result of the opening Europa League group games by winning 2-0 at PSV Eindhoven.
The Bulgarian side were only founded in 2001 and goals from Roman Bezjak and Virgil Misidjan ensured they made a winning start against the Dutch side.
Russian outfit Rubin Kazan, in the same group as Wigan, won 5-2 at Slovenia's Maribor.
Kazan always led but needed last-minute goals from Jose Salomo Rondon and Aleksandr Ryazantsev to secure the win.
Swansea are top of Group A although St Gallen of Switzerland are only one goal behind courtesy of goals from Goran Karanovic and Marco Mathys in a 2-0 victory over Russian side Kuban Krasnodar.
Other British representatives Tottenham, lead the way in Group K after Sheriff Tiraspol played out a goalless draw against Russian side Anzhi Makhachkala in Moldova.
Elsewhere English referee Andre Marriner sent off Bordeaux's Lucas Orban as Eintracht Frankfurt won 3-0 at home.
It was the German side's first European match for six years and they were already three goals in front, through Vaclav Kadlec, Marco Russ and Constant Djakpa before Orban was dismissed for fouling Stefan Aigner.
On-loan Manchester United forward Bebe had a disappointing evening as his Portuguese side Pacos Ferreira were beaten 3-0 in Italy at Fiorentina, with goals from Gonzalo Rodríguez, Matos Ryder and Giuseppe Rossi.
Former Portsmouth and Bolton defender Tal Ben Haim suffered late frustration as his Belgian club Standard Liege were beaten 2-1 by Danish side Esbjerg - Mushaga Bakenga's winner arriving in the fifth-minute of stoppage time.
French side Lyon, who failed to make the group stages of the Champions League for the first time since 2002, could only collect a point from a game of few chances in a goalless draw at Spain's Real Betis.
Italian club Lazio won 1-0 at home against Legia Warsaw of Poland in Group J, courtesy of Brazilian midfielder Hernanes' second-half goal.