Shrewsbury have midfielder Jon Taylor back from his one-game ban, but are now minus suspended defender Dave Winfield.
Paul Parry (hip) is also available after injury, while summer arrival John Marsden (foot) is finally fit to make his first appearance up front.
Carlisle striker Lewis Guy is hoping to recover from illness in time.
But the visitors will again be without fellow forward Lee Miller due to a torn calf muscle, so Mark Beck is expected to start again.
Carlisle boss Graham Kavanagh officially takes charge of his first game, having been appointed as Greg Abbott's successor on Monday after steering the Cumbrians to three straight wins.