Swansea City striker Michu has been called into the Spain squad for the first time for the decisive World Cup qualifiers against Belarus and Georgia.
He replaces David Villa after the Atletico Madrid forward injured his ankle in a 2-1 win against Celta Vigo.
Michu joined the Swans for £2m in 2012 and hit 22 goals in his debut season.
The 27-year-old was selected by Spain boss Vicente del Bosque ahead of Tottenham's Roberto Soldado and Juventus forward Fernando Llorente.
Spain are guaranteed to finish in the top two of their group, along with France, but the 2010 winners need four points from their remaining two home games to be certain of qualifying.
Belarus visit Palma on Friday night with Albacete hosting the game against Georgia four days later.
La Rioja have already replaced Napoli defender Raul Albiol with Real Sociedad's Inigo Martinez and are without injured Chelsea striker Fernando Torres.
Atletico Madrid's Brazil-born frontman Diego Costa has switched allegiance to Spain, but they are yet to receive clearance to play him.
Del Bosque had suggested Michu would feature in Spain's friendly against Uruguay earlier this year but did not call him up.
Goalkeepers: Iker Casillas (Real Madrid), Victor Valdes (Barcelona), Pepe Reina (Napoli).
Defenders: Alvaro Arbeloa (Real Madrid), Sergio Ramos (Real Madrid), Gerard Pique (Barcelona), Inigo Martinez (Real Sociedad), Nacho Monreal (Arsenal), Juanfran (Atletico Madrid), Alberto Moreno (Sevilla).
Midfielders: Andres Iniesta (Barcelona), Isco (Real Madrid), Koke (Atletico Madrid), Xavi (Barcelona), Mario Suarez (Atletico Madrid), Sergio Busquets (Barcelona), Cesc Fabregas (Barcelona), Juan Mata (Chelsea), David Silva (Manchester City).
Forwards: Jesus Navas (Manchester City), Alvaro Negredo (Manchester City), Pedro (Barcelona), Michu (Swansea).