Italian league leaders Roma, who have won all eight games so far, visit 11th-placed Udinese on Sunday.
Earlier this week, Roma chief executive that they want to be the "best club in the world".
Title contenders Napoli host Torino, while Juventus are at home to Genoa. Fiorentina, who are sixth, visit Chievo.
AC Milan will look to get their shaky season going when they visit Parma. Bologna host Livorno, Catania face Sassuolo and Lazio are at home to Cagliari.
Freiburg are at home to Hamburg and Borussia Monchengladbach host Eintracht Frankfurt.
Second-placed Atletico Madrid host Real Betis in Sunday's big game. Sevilla host Osasuna, Valencia are at Villarreal and Real Sociedad are at home to Almeria.
The biggest games in Ligue 1 are both on Sunday, as leaders Paris St-Germain go to St Etienne and Monaco host Lyon. Bordeaux are at home to Montpellier in the day's other game.
ELSEWHERE IN EUROPE
Portugal's two unbeaten sides face each other in a top-of-the-table match, with leaders FC Porto hosting Sporting Lisbon. Roberto Mancini's Galatasaray visit Kayserispor in the Turkish Super Lig.
In the Netherlands, surprise package PEC Zwolle host AZ Alkmaar and PSV visit Roda JC.