Match ends, Leyton Orient 0, Preston North End 1.
Leyton Orient fell to only their second league defeat of the season as Joe Garner's goal gave Preston victory to knock the hosts off top spot.
The visitors took the lead when Garner struck a wonderful first-time volley beyond keeper Jamie Jones from Keith Keane's cross.
The O's struggled to create and their best chance saw Bailey Wright's last-ditch tackle deny David Mooney.
Robbie Simpson forced Declan Rudd into a late save as Preston held on.
Russell Slade's side had scored in all their previous 15 league games and are the Football League's top scorers with 36 but drop to second after Wolves won at struggling Notts County.
Despite becoming the first team to take all three points away from Brisbane Road since February, Preston drop down a place to fifth after Brentford's big win over Crewe.
VIEW FROM THE DRESSING ROOM
Leyton Orient manager Russell Slade told BBC London 94.9:
"It was a tight game. Preston bossed it and made life tough for us in the first half by slowing the game down and dictating the tempo.
"They didn't create a lot either. It was cagey and we grew into it and had a wonderful window of opportunity to equalise late on.
"[Suspended midfielder] Romain Vincelot is the heartbeat of the team and he was missed today.
"We knew today would be tough as they set their stall out and were pretty negative. We are disappointed but are still up there and have the chance for a fine season."
- 3SawyerSubstituted forBattat 62'minutes
- 8JamesSubstituted forBaudryat 70'minutes
- 15ClarkeBooked at 35mins
- 10MooneySubstituted forSimpsonat 81'minutes
- 7CoxBooked at 90mins
- 7HumphreySubstituted forHuntingtonat 90'minutes
- 2KeaneBooked at 41mins
- 9DaviesBooked at 90mins
- 14GarnerBooked at 43mins
- 12GallagherSubstituted forKilkennyat 83'minutes
- Keith Hill
- Shots on Target
Second Half ends, Leyton Orient 0, Preston North End 1.
Attempt saved. Robbie Simpson (Leyton Orient) right footed shot from the left side of the box is saved in the centre of the goal.
Attempt missed. Joe Garner (Preston North End) right footed shot from outside the box is too high.
Dean Cox (Leyton Orient) is shown the yellow card.
Foul by Mathieu Baudry (Leyton Orient).
Joe Garner (Preston North End) wins a free kick in the attacking half.
Kevin Davies (Preston North End) is shown the yellow card.
Mathieu Baudry (Leyton Orient) wins a free kick in the defensive half.
Foul by Kevin Davies (Preston North End).
Substitution, Preston North End. Paul Huntington replaces Chris Humphrey.
Foul by Marvin Bartley (Leyton Orient).
Declan Rudd (Preston North End) wins a free kick in the attacking half.
Corner, Leyton Orient. Conceded by Declan Rudd.
Shaun Batt (Leyton Orient) wins a free kick in the defensive half.
Foul by Tom Clarke (Preston North End).
Corner, Leyton Orient. Conceded by Neil Kilkenny.
Attempt blocked. Marvin Bartley (Leyton Orient) right footed shot from outside the box is blocked.
Foul by Dean Cox (Leyton Orient).
Keith Keane (Preston North End) wins a free kick in the attacking half.