Liverpool striker Luis Suarez has been named in Uruguay's 23-man World Cup squad, despite his recent knee surgery.
Suarez, 27, had an operation on 22 May to repair meniscus damage, but hopes to play in his country's opening Group D match, against Costa Rica on 14 June.
Three other Premier League players have been selected by coach Oscar Tabarez.
Liverpool defender Sebastian Coates, Southampton midfielder Gaston Ramirez and West Brom defender Diego Lugano will also travel to Brazil.
Suarez has told Liverpool team-mate Glen Johnson he thinks he will be "OK" for the game against England on 19 June.
Coates, 23, spent the second half of the season on loan at former club Nacional after recovering from a knee injury that meant he missed Uruguay's last four South American qualifiers and the play-off win over Jordan.
Ramirez, also 23, is heading to his first World Cup finals, as are centre-back Jose Maria Gimenez, 19, and Atletico Madrid team-mate Cristian Rodriguez, 28.
Former Manchester United striker Diego Forlan, 35, will take part in his third World Cup, having played and scored at both the 2002 and 2010 tournaments.
The two players cut from Tabarez's 25-man provisional squad are Palmeiras midfielder Sebastian Eguren and Lanus defender Alejandro Silva.
After facing Costa Rica and England, Uruguay conclude their Group D fixtures with a game against Italy on 24 June.
Goalkeepers: Fernando Muslera (Galatasaray), Martin Silva (Vasco da Gama), Rodrigo Munoz (Libertad).
Defenders: Maximiliano Pereira (Benfica), Diego Lugano (West Bromwich Albion), Diego Godin, Jose Maria Gimenez (both Atletico Madrid), Sebastian Coates (Liverpool), Martin Caceres (Juventus), Jorge Fucile (Porto).
Midfielders: Alvaro Gonzalez (Lazio), Alvaro Pereira (Sao Paulo), Walter Gargano (Parma), Egidio Arevalo Rios (Morelia), Diego Perez (Bologna), Cristian Rodriguez (Atletico Madrid), Gaston Ramirez (Southampton), Nicolas Lodeiro (Botafogo).
Forwards: Luis Suarez (Liverpool), Edinson Cavani (Paris St-Germain), Abel Hernandez (Palermo), Diego Forlan (Cerezo Osaka), Christian Stuani (Espanyol).