Champions The New Saints will host play-off winners Bangor City on the opening weekend of the Welsh Premier League season.
Newly promoted Cefn Druids are at home to Aberystwyth Town in their first game in the top-flight since 2010.
Both matches, along with Prestatyn v Gap Connah's Quay, will be played on Friday, 22 August.
The second round of matches will be played on August Bank Holiday Monday for the second season running.
Friday, 22 August
Cefn Druids v Aberystwyth Town
Prestatyn Town v Gap Connahs Quay
The New Saints vBangor City
Saturday, 23 August
Airbus UK Broughton v Port Talbot Town
Carmarthen Town v Rhyl
Newtown v Bala Town
Monday, 25 August
Aberystwyth Town v The New Saints
Bala Town v Airbus UK Broughton
Bangor City v Newtown
Gap Connahs Quay v Carmarthen Town
Port Talbot Townv Prestatyn Town
Rhyl v Cefn Druids