On-loan Manchester City defender Micah Richards made his debut as Fiorentina started their Europa League campaign with a 3-0 win over Guingamp.
Richards, 26, replaced ex-City team-mate Stefan Savic just before the hour.
Juan Vargas, Juan Cuadrado and Federico Bernardeschi all scored for the Italians as Vincenzo Montella's men had a simple win against the French side, who had Moustapha Diallo sent off.
Elsewhere Danilo D'Ambrosio's goal gave Inter Milan a 1-0 win at Dnipro.
Rafael Benitez's Napoli fell behind to an early goal from Sparta Prague's Josef Husbauer but Gonzalo Higuain's penalty pulled the Italians level before two goals from Dries Mertens earned a 3-1 win.
|Richards' search for action|
|Richards, who has one year left on his Manchester City contract, has not started a match since City's 2-1 FA Cup defeat by Wigan in March.|
Defending champions Sevilla took a quick two-goal lead with Gerard Deulofeu setting up goals for Grzegorz Krychowiak and Stephane Mbia as the Spanish side beat Feyenoord 2-0.
Dimitris Papadopoulos scored a first-half hat-trick as PAOK Salonika produced a comprehensive 6-1 win over Dinamo Minsk, Steaua Bucharest had a thumping 6-0 win over AaB Aalborg and Young Boys had a 5-0 victory against Slovan Bratislava.
With Tottenham drawing 0-0 at Partizan Belgrade, the other match in Group C saw Besiktas held 1-1 by Asteras Tripolis.
Everton and their Group H opponents Lille and Krasnodar shared a 1-1 draw.
In Celtic's group, Dinamo Zagreb had a 5-1 win over Romanians Astra.