Manchester City will face CSKA Moscow inside an empty stadium after the Russian club was ordered to play its next three Champions League home games behind closed doors.
Uefa has punished CSKA for a series of offences, including racist chanting.
CSKA's fans will also be prevented from attending their remaining two away Champions League group games.
City, winless in the Champions League this season, travel to Moscow on 21 October and host CSKA two weeks later.
CSKA were found guilty of racist chanting during last season's Champions League, including one highlighted in a complaint by Yaya Toure when City and CSKA met last in October 2013.
But at this season's Champions League opener at Roma on 17 September, there was further trouble when Russian supporters were involved in disruption with the local police and threw flares inside the Stadio Olimpico during their 5-1 defeat.
Uefa found CSKA's supporters guilty of several offences, including "racist behaviour of supporters, crowd disturbance, setting off/throwing of fireworks and missiles".
In a statement, Uefa said: "The European governing body has a zero-tolerance policy towards racism and discrimination on the field and in the stands.
"All forms of racist behaviour are considered serious offences against the disciplinary regulations and are punished with the most severe sanctions."
The Moscow club, who have also been fined £156,900, had already played their first Champions League home match against Bayern Munich on 30 September behind closed doors as punishment for their fans' racist behaviour last season.