Manchester City midfielder Yaya Toure, Swansea striker Wilfried Bony and West Ham top scorer Diafra Sakho are among the Premier League players who may miss club games in the new year to compete in the Africa Cup of Nations.
The final six nations to qualify were confirmed on Wednesday.
Newcastle and West Ham could lose three players each during the tournament between 17 January and 8 February 2015.
Equatorial Guinea are the hosts following Morocco's withdrawal.
Morocco had expressed fears an influx of foreign fans could help spread the Ebola epidemic, which has mainly affected the West African countries of Sierra Leone, Liberia and Guinea.
Reigning Afcon champions Nigeria will not defend their crown, having failed to qualify for the finals.
|Club-by-Club - Premier League players set to miss games for Afcon|
|Crystal Palace||Adlene Guediora (Algeria)Yannick Bolasie (DR Congo)|
|Everton||Christian Atsu (Ghana)|
|Hull City||Mohamed Diame (Senegal)|
|Leicester City||Riyad Mahrez (Algeria)Jeff Schlupp (Ghana)|
|Liverpool||Kolo Toure (Ivory Coast)|
|Manchester City||Yaya Toure (Ivory Coast)|
|Newcastle United||Mehdi Abeid (Algeria)Papiss Cisse (Senegal)Cheick Tiote (Ivory Coast)|
|Southampton||Emmanuel Mayuka (Zambia)Sadio Mane (Senegal)|
|Stoke City||Mame Biram Diouf (Senegal)|
|Swansea||Wilfried Bony (Ivory Coast)|
|Tottenham||Nabil Bentaleb (Algeria)|
|West Ham United||Alex Song (Cameroon)Cheikhou Kouyate (Senegal)Diafra Sakho (Senegal)|
|West Bromwich Albion||Youssouf Mulumbu (DR Congo)|
|Club-by-Club - Football League players set to miss games for Afcon|
|Bournemouth||Tokelo Rantie (South Africa)|
|Cardiff City||Bruno Ecuele Manga (Gabon)|
|Charlton||Frederic Bulot (Gabon)|
|Middlesbrough||Albert Adomah (Ghana)|
|Peterborough||Gabriel Zakuani (DR Congo)|
|Sheffield Wednesday||Kamil Zayatte|
|Wolverhampton Wanderers||Nouha Dicko - MaliBakary Sako - Mali|