Match ends, Barnsley 2, Leyton Orient 0.
Conor Hourihane slotted his 10th league goal of the season as Barnsley boss Danny Wilson's 1,000th game as a manager ended in victory.
Kane Hemmings split Orient's defence early in the first half and Hourihane rounded keeper Adam Legzdins to score.
Dale Jennings then crossed to Devante Cole, who easily found the corner.
Dean Cox twice came close for Orient, but Barnsley held out for a clean sheet despite keeper Ross Turnbull being sent off for handling outside the box.
Barnsley manager Danny Wilson told BBC Radio Sheffield:
"It was full of commitment, great application, great attitude, two terrific goals.
"It was backs against the wall second half, particularly with the second half, so all those ingredients were there for us today.
"The pleasing thing is that we came off the back of a very good win at Chester and continued with that type of performance, which is great."
Leyton Orient winger Dean Cox told BBC London 94.9:
"It was a bad start and we didn't really create much, but we take spirit from the second half performance. We're a bit low on confidence.
"Obviously with four managers in a season, it's not great from any stretch of the imagination for the players. But it's the cards we've been dealt with and we're trying our best to get these results.
"The previous managers have had different ideas to the one we've got now so it's difficult to implement exactly he wants on the pitch.
"Obviously the language barrier is a bit difficult from the sidelines when he's trying to give instructions. Some of the lads don't understand what he's saying, so it's difficult."
- 1TurnbullBooked at 73mins
- 44ColeSubstituted forDaviesat 74'minutes
- 10HemmingsBooked at 58minsSubstituted forLitaat 71'minutes
- 2OmozusiSubstituted forBaudryat 45'minutes
- 17WrightSubstituted forCoxat 53'minutesBooked at 66mins
- 11McAnuffBooked at 67mins
- 30PlasmatiSubstituted forMooneyat 17'minutes
- Mark Brown
- Shots on Target
Second Half ends, Barnsley 2, Leyton Orient 0.
Attempt saved. Dean Cox (Leyton Orient) right footed shot from outside the box is saved in the centre of the goal.
Leroy Lita (Barnsley) wins a free kick in the defensive half.
Foul by Mathieu Baudry (Leyton Orient).
Dale Jennings (Barnsley) wins a free kick in the defensive half.
Foul by Romain Vincelot (Leyton Orient).
Luke Berry (Barnsley) wins a free kick in the defensive half.
Foul by Bradley Pritchard (Leyton Orient).
Foul by Luke Berry (Barnsley).
David Mooney (Leyton Orient) wins a free kick in the defensive half.
Attempt missed. Shane Lowry (Leyton Orient) left footed shot from outside the box is too high from a direct free kick.
Substitution, Barnsley. Adam Davies replaces Devante Cole.
Ross Turnbull (Barnsley) is shown the red card for hand ball.
Shaun Batt (Leyton Orient) wins a free kick in the defensive half.
Foul by Ross Turnbull (Barnsley).
Substitution, Barnsley. Leroy Lita replaces Kane Hemmings.
Jobi McAnuff (Leyton Orient) wins a free kick in the attacking half.
Foul by Mason Holgate (Barnsley).
Corner, Barnsley. Conceded by Mathieu Baudry.