|Africa Cup of Nations 2015|
|Host: Equatorial Guinea. Dates: 17 January - 8 February.|
|Coverage: Live text commentary and reports on every game, plus all the latest news from the tournament, on the BBC Sport website.|
Manchester City midfielder Yaya Toure is the highest-profile name among 19 players departing the Premier League this month to compete in the Africa Cup of Nations or Asian Cup.
If Ivory Coast go all the way to the Africa Cup of Nations final on 8 February, Toure would be absent for at least five matches, including the top-of-the-table game against Chelsea on 31 January.
However, the 31-year-old could return for the trip to Stamford Bridge - having missed three matches - if the Elephants fail to reach the knockout stage.
Champions City are not the only side ruing the loss of key men to this month's two international tournaments.
Twelve Premier League clubs are without players who will be at Afcon - which takes place between 17 January and 8 February - and the three-week long Asia Cup, which begins on Friday. A total of 16 players are in Equatorial Guinea and three in Australia.
Champions League-chasing Southampton and relegation-threatened Crystal Palace are the hardest hit, having each lost three players who have played first-team football for them this season.
Palace will continue their battle against the drop without influential duo Yannick Bolasie and Mile Jedinak, both of whom have played more than 1,600 minutes of top-flight football this season.
As well as crucial league matches, there is also a risk that top-flight clubs could be depleted for vital FA Cup and League Cup ties - although the length of a player's absence depends on how far their nation progresses.
|Club-by-club - Premier League players set to miss games while at Afcon & Asian Cup|
|Club||Players||Key stats (eg goals, chances created, minutes played)|
|Crystal Palace||Yannick Bolasie (DR Congo)||1,688 mins; 26 chances|
|Adlene Guedioura (Algeria)||45 mins; 38 passes|
|Mile Jedinak (Australia)||1,617 mins; 5 goals|
|Kwesi Appiah (Ghana)||Has been on loan at Cambridge|
|Everton||Christian Atsu (Ghana)||70 mins; 41 passes|
|Leicester City||Riyad Mahrez (Algeria)||1,216 mins; 23 chances|
|Liverpool||Kolo Toure (Ivory Coast)||551 mins; 16 tackles|
|Manchester City||Yaya Toure (Ivory Coast)||1,523 mins; 7 goals|
|Wilfried Bony (Ivory Coast)||1,302 mins; 9 goals|
|Newcastle United||Papiss Cisse (Senegal)||633 mins; 9 goals|
|Cheick Tiote (Ivory Coast)||898 mins; 34 tackles|
|Southampton||Sadio Mane (Senegal)||934 mins; 7 goals|
|Emmanuel Mayuka (Zambia)||49 mins; 14 passes|
|Maya Yoshida (Japan)||772 mins; 401 passes|
|Stoke City||Mame Biram Diouf (Senegal)||1,354 mins; 5 goals|
|Swansea City||Ki Sung-yueng (South Korea)||1,728 mins; 16 chances|
|Tottenham Hotspur||Nabil Bentaleb (Algeria)||848 mins; 635 passes|
|West Ham United||Cheikhou Kouyate (Senegal)||1,328 mins; 45 tackles|
|West Bromwich Albion||Youssouf Mulumbu (DR Congo)||724 mins; 503 passes|
|* 2014-15 Premier League stats correct on 8 January|
The 'medical joker'
Teams competing in the Africa Cup of Nations had to finalise their 23-man squads on Wednesday - but there is room for manoeuvre.
Senegal boss Alain Giresse is still monitoring the fitness of Southampton midfielder Sadio Mane, despite Saints boss Ronald Koeman ruling the player out of the tournament with a calf injury.
Former France midfielder Giresse revealed he may use a "medical joker" - a provision that allows him to call up a player up to 48 hours before the country's first game (against Ghana on 19 January) - in order to give the 22-year-old the greatest chance of recovering in time.
There might have been significantly more Premier League involvement in the Cup of Nations but injury forced the late withdrawal of several players.
Diafra Sakho has scored eight league goals for West Ham this season and Senegal wanted to include him in their squad but the 25-year-old suffered a recurrence of a back injury playing against West Brom on 1 January and has not been included.
The Hammers might also have lost the influential Alex Song but after an on-off saga of whether he would play for Cameroon, the 27-year-old announced his retirement from international football.
Versatile Jeffrey Schlupp, with three league goals for Leicester, has pulled out of the Ghana squad through injury, although Kwesi Appiah, who has been on loan at Cambridge from Crystal Palace, has been included.
Newcastle midfielder Mehdi Abeid also misses out, withdrawing from the Algeria squad with a toe injury.
Some notable absentees from the Championship include Bournemouth's Tokelo Rantie (South Africa), Cardiff's Bruno Ecuele Manga (Gabon), Charlton's Frederic Bulot (Gabon), Sheffield Wednesday's Kamil Zayatte (Guinea), Wolves' Bakary Sako (Mali) and Middlesbrough's Emilio Nsue (Equatorial Guinea).
League One players away on international duty include Doncaster's Dean Furman (South Africa), Peterborough's Gabriel Zakuani (DR Congo), Swindon's Massimo Luongo (Australia) and Yaser Kasim (Iraq).
|Domestic schedule during Afcon/Asian Cup|
|10-11 Jan||Premier League|
|14 Jan||FA Cup third-round replays|
|17-19 Jan||Premier League|
|20-21 Jan||League Cup semi-finals first legs|
|23-26 Jan||FA Cup fourth round|
|27-28 Jan||League Cup semi-finals second legs|
|31 Jan-1 Feb||Premier League|
|7-8 Feb||Premier League|