Louis van Gaal tipped his Manchester United side to win the FA Cup after their 3-0 win over Cambridge United.
Goals from Juan Mata, Marcos Rojo and James Wilson sealed a fifth-round trip to League One Preston.
United are the highest-placed side remaining in the competition and Van Gaal believes that allows them to be considered favourites.
"I am not a casino man," he said. "I am not allowed to bet. But I give you a tip. We have a real chance now."
United are joint record winners of the competition with Arsenal. But the last of their 11 wins came in 2004 and Darren Fletcher's departure to West Brom on deadline day means no current United player has won the competition during their time at Old Trafford.
"We are the highest qualified team in the FA Cup so our status is the highest club," added Van Gaal.
"But Arsenal is still in the cup and also a very high competitor. Liverpool is also there and will fight (against Bolton) tomorrow."
|FA Cup fifth-round draw|
|Crystal Palace v Liverpool or Bolton Wanderers||Arsenal v Middlesbrough|
|Aston Villa v Leicester City||West Brom v West Ham|
|Bradford City v Sunderland||Blackburn Rovers v Stoke City|
|Derby County v Reading||Preston North End v Manchester Utd|
Unexpected defeats for the Premier League's top two, Chelsea and Manchester City, have created the opportunity for Van Gaal to win the domestic cup in a fourth country after his previous successes with Ajax, Barcelona and Bayern Munich.
And, despite the potential for an upset, Van Gaal is happier being paired with a lower league team than a top-flight rival.
"I prefer to play against lower teams because the possibility to survive is higher," he said.
"The FA Cup is a title and I am living for titles.
"It is not as important for the coach as the club, the fans and the players. That is the sequence.
"But I won a title in my first year everywhere where I worked."
Van Gaal confirmed he replaced striker Robin van Persie with 24 minutes remaining purely as a precaution ahead of this weekend's encounter with West Ham.