Wales will be without Wigan midfieler Emyr Huws for their Euro 2016 qualifier away to Group B leaders Israel on 28 March.
Huws, 21, suffered a serious injury in training.
Wigan manager Malky Mackay has confirmed that Huws will be out for "three to four months" with the problem.
He joined from Manchester City on loan last summer before joining them permanently in September, 2014.
Huws came on as a late substitute in the 0-0 draw against Belgium in November to win his fourth Wales cap.