Carlisle goalkeeper Mark Gillespie will miss up to six weeks with a torn groin, while midfielder David Symington has suffered a major blow in his comeback.
Gillespie, 22, has missed the League Two strugglers' last two games - both of which have ended in defeat.
Midfielder Symington, 21, was injured playing on loan for non-league side Workington at the weekend.
"There was press saying he's dislocated a knee or fractured his ankle," manager Keith Curle told BBC Radio Cumbria.
"Rather than add to rumours, what we can say is David was released from hospital on Sunday and we're waiting for the reports to be assessed."
Symington has made 15 appearances for the Cumbrians this season but has not played for the first team since 28 December.
He joined Workington on a month's loan last Friday and was injured playing in his first match.