Plymouth Argyle will host the England Under-20 side's friendly against the USA on Sunday, 29 March.
It will be the first England game to be held at Home Park since the Under-21s beat Poland 2-1 in 1989.
Former Argyle youngsters Lloyd Jones (Liverpool) and Christian Walton (Brighton) have been included in previous England Under-20 squads.
Exeter goalkeeper Christy Pym has also been in the team, as has former Grecians midfielder Matt Grimes.
"We are delighted to be hosting this prestige friendly and that international football is returning to Plymouth," said Argyle chief executive Martyn Starnes.
"We are sure the West country's football fans will help make it an occasion to remember."