Republic of Ireland midfielder Darron Gibson has pulled out of Sunday's Euro 2016 qualifier against Poland in Dublin because of a groin injury.
The Everton player has been unable to train since joining up with the squad in Malahide because of the problem, and was withdrawn on Wednesday afternoon.
Burnley full-back Stephen Ward also has an ankle problem and is rated doubtful.
But Wigan winger James McClean has declared himself fit after a scan on an ankle injury.
McClean, who limped out of training on Tuesday, said he is "100%" sure he will be fit to face the Poles at the Aviva Stadium.
He was sent for a scan on his left ankle and has allayed fears that he could miss the game.
"It's been positive news, just plenty of rest, plenty of ice and I should be ready to go. You'd have to chop my foot off otherwise," said McClean.
"I'm fine. It's a bit sore, but it's just bone bruising. A couple of days rest and it should be fine."
|Republic of Ireland v Poland recent meetings|
|November 2013: Poland 0-0 Rep of Ireland - friendly|
|February 2013: Rep of Ireland 2-0 Poland - friendly|
|November 2008: Rep of Ireland 2-3 Poland|
|April 2004: Rep of Ireland 0-0 Poland|
|November 1991: Poland 3-3 Rep of Ireland|
|May 1991: Rep of Ireland 0-0 Poland|
The results of the scan came as a relief to McClean, who admitted he was concerned when he was forced to curtail his involvement.
"I was, yes, because I didn't remember getting a kick or going over on it, and obviously that's the worrying part," he said.
"In pre-season, I did my other ankle, so that was kind of on my mind. But I went for the scan and it came back positive and I'm happy with how it came back.
"I spoke to the medical staff and we agreed that it was best just to give it that extra 24, 48 hours extra rest. The game is not until Sunday."
McClean and Ward were unable to take part in a training session at the Aviva Stadium on Wednesday morning.
The Republic side opened their campaign with victories in Georgia and at home to Gibraltar followed by a 1-1 draw in Germany and then the defeat in Scotland.
Poland have a three-point lead over Germany, Scotland and Ireland at the top of the table having beaten the world champions 2-0 in Warsaw in October before being held to a 2-2 draw by the Scots.