West Brom will pay tribute to former striker Jeff Astle by wearing a replica 1968 FA Cup final kit at home to Leicester on 11 April.
Astle, who scored 174 goals in 361 games for the club, netted the winner as Albion beat Everton 1-0 at Wembley.
The kit will be part of 'Astle Day' where his family will launch a foundation to help sufferers and research of the brain condition which caused his death in 2002.
The England cap was 59 when he died.
The condition - chronic traumatic encephalopathy - is usually linked to boxing.
And Astle's family have been lobbying the Football Association to introduce new laws on head injuries in amateur football.
Albion will wear shirts numbered 2-11, with a blank goalkeeping jersey to mirror the one worn by John Osborne at Wembley.
It will be the second time the Premier League has granted permission for a kit change following Manchester United's switch to a retro design for the 50th anniversary of the Munich air disaster in 2008.