With all Premiership issues decided, the focus turns to the race for promotion from the Championship.
Leaders Carrick Rangers go into their final game against relegated Dundela knowing a win would give them the title and automatic promotion.
A draw opens the door to Bangor, who are two points behind but boast a superior goal difference.
The Seasiders visit Lisburn Distillery but if they lose Ards can nip in and secure the play-off place.
Ards have a home game against Ballyclare Comrades and only three points and defeat for Bangor will set them up for a promotion/relegation play-off with Warrenpoint Town.
Carrick and Bangor are vying to take the place of Institute, who will end their stay in top-flight football with a Section B game against Coleraine at the Showgrounds.
A number of familiar faces of Irish League football will bring their careers to an end in Saturday's final round of Premiership fixtures.
Glenavon defender William Murphy, who played 639 times for Linfield, will retire following the match at Crusaders.
Ballymena United defender Davy Munster will bow out after the match with Dungannon Swifts while Cliftonville full-back Ronan Scannell plays his last game against Glentoran.
There will be celebrations at Seaview as Crusaders finally get their hands on the Gibson Cup.
The official presentation to the Premiership champions will take place after their game with the Lurgan Blues.
Saturday 25 April (15:00 BST)
Crusaders v Glenavon
Glentoran v Cliftonville
Portadown v Linfield
Ballymena Utd v Dungannon Swifts (14:00)
Ballinamallard Utd v Warrenpoint Town
Coleraine v Institute
Ards v Ballyclare Comrades
Carrick Rangers v Dundela
Lisburn Distillery v Bangor