Memphis Depay scored a stunning free-kick in his last home match for PSV before joining Manchester United.
The 21-year-old forward, who is set to join United in a deal worth about £30m at the end of the season, powered home with a swerving right-footed strike to open the scoring against Heracles.
Jetro Willems sealed the win to leave PSV, already crowned Dutch champions, 10 points clear of second-placed Ajax.
PSV's fans thanked Depay with a banner reading: 'Dreamchaser of Eindhoven.'
United boss Louis van Gaal, who managed Depay in his previous role with the Netherlands, said United were "forced" into signing the Dutchman in the light of rival interest from Paris St-Germain.
Depay is the youngest player to have scored more than 15 times in the Europe's top 10 leagues this season, with his tally now standing at 22 league goals.
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