Manchester United boss Louis van Gaal admits David De Gea's transfer saga is causing a problem.
The 24-year-old goalkeeper wants to join Real Madrid but United have said they will not discuss a deal unless Real defender Sergio Ramos is included.
Real boss Rafael Benitez has said Ramos, 29, is staying at the Bernabeu.
"We have a situation that is not favourable for David De Gea, neither for us and neither for the club that, maybe, he wants to go," said Van Gaal.
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Spain goalkeeper De Gea was replaced at half-time as United slipped to a 2-0 defeat by Paris St-Germain in Wednesday night's International Champions Cup game in Chicago.
Meanwhile, the Dutch boss admits he has "no idea" of the whereabouts of club-record signing Angel Di Maria.
Argentina midfielder Di Maria, a £59.7m buy from Real Madrid last summer, failed to return for pre-season training on Saturday as scheduled and it is understood talks are ongoing with PSG about a move to the French champions.
Asked if he knew where the 27-year-old was, Van Gaal said: "Maybe you know."
When the journalist said he did not, Van Gaal said: "I don't know either."
Speaking after the match, PSG coach Laurent Blanc said: "Manchester United and PSG are two big clubs and negotiations can be difficult, but we are close to the end."
Blanc added it was up to United to say whether his club has been given permission to speak to Di Maria.
Wednesday's defeat by the Ligue 1 side was convincing.
Blaise Matuidi and Zlatan Ibrahimovic both profited from defensive mistakes to score two goals in seven first-half minutes.
Phil Jones started alongside Daley Blind in central defence, with Luke Shaw and Matteo Darmian occupying the full-back positions.
It appears England international Jones's place for the Premier League opener against Tottenham on 8 August is most at risk as he was the only member of that starting defence not to be singled out by his manager after the match.
"I think that I shall play Shaw with Daley Blind in the left central position," said Van Gaal.
"The right central defensive position I have to consider.
"But I am very pleased with the performance of Matteo Darmian."