Brentford boss Marinus Dijkhuizen says he is resigned to losing highly-rated full-back Moses Odubajo.
But Dijkhuizen said 24-year-old striker Andre Gray would not be allowed to leave Griffin Park amid interest from Hull City.
Odubajo, 22, has also been the subject of a bid from Hull and missed the Bees' friendly against Norwich.
"I think Moses will not be in the squad any more so that's a big loss for us," the Dutchman told BBC London 94.9.
"Hull bid for him last week and he decided for himself that he didn't want to play in the friendly, he wants to leave. He said it's a big opportunity for him.
"I expect a Premier League club to bid because he's a very good player and there aren't a lot of good right-backs around."
Odubajo, who has represented England at Under-20 level, has made 49 appearances for the Bees since signing from Leyton Orient for £1m in June 2014.
Gray scored 18 goals for Brentford last season in his first campaign in the Championship after signing from Luton Town, but Dijkhuizen said it was "easy" for the club to turn down the offer from Hull.
Meanwhile, Brentford's Northern Ireland international winger Stuart Dallas has joined Leeds United and midfielder Jonathan Douglas has left for Ipswich Town, according to reports by BBC Suffolk.