Match ends, Burnley 1, Brentford 0.
Michael Keane's header gave Burnley their first win of the season to end Brentford's unbeaten league start.
Sean Dyche's side, who were relegated from the Premier League last term, had taken only two points from their opening three Championship games.
Defender Keane nodded in a David Jones corner at the back post on 26 minutes to seal victory over the Bees.
Striker Andre Gray, who joined Burnley from Brentford for a reported £9m on Friday, was not involved at Turf Moor.
With club-record signing Gray watching from the stands, Burnley gave a first start to German forward Rouwen Hennings, the Clarets' recent signing from Karlsruher.
Brentford, whose midweek home game with Birmingham City was postponed to allow their Griffin Park pitch to be re-laid, had chances to go in front before Keane's first-half winner.
Clarets goalkeeper Tom Heaton pushed away Alan Judge's free-kick, then kept out two shots from Lasse Vibe before Keane netted for the second consecutive home match.
The former Manchester United centre-back was a constant threat from set-pieces, heading another Burnley corner over the bar before half-time.
Scott Arfield shot off target for the hosts either side of the interval, while substitute Sam Vokes was unable to find the net from 10 yards following Michael Kightly's dummy and Matt Taylor sent a free-kick wide.
Burnley manager Sean Dyche:
"Overall, there's more to come. I'm absolutely 100% sure on that and Andre will bring something different. There's no guarantee, but Andre Gray's very hungry for success.
"I said we want to be productive in the market and we're still out there if the right move comes along. It's a tough market though. People are not letting their players go easily - neither did we.
"We deserved it in the end. There were some nerves around in the first half. Everyone wanted that first win. It was important to get it."
Brentford boss Marinus Dijkhuizen:
"It's difficult to lose Andre Gray. His goals won a lot of points. But it's been going on for a couple of weeks and now we can go on and start looking for a replacement.
"Is it a relief? Yes and no. I had a good relationship with him, and we now don't have a replacement on the bench so we are in need of two strikers.
"We were a bit unlucky to lose. We played the first half better. We had good energy and put pressure on the ball and created some very good chances. But we had to score."
- 4DuffBooked at 16mins
- 11KightlySubstituted forTaylorat 73'minutes
- 18HenningsSubstituted forVokesat 60'minutes
- 19JutkiewiczSubstituted forSordellat 83'minutes
- 12McCormackBooked at 45minsSubstituted forUdumagaat 83'minutes
- 20DiagouragaBooked at 53mins
- 24GogiaSubstituted forColinat 58'minutes
- David Webb
- Shots on Target
Second Half ends, Burnley 1, Brentford 0.
Corner, Burnley. Conceded by James Tarkowski.
Attempt blocked. Harlee Dean (Brentford) header from the centre of the box is blocked. Assisted by Jake Bidwell.
Jake Bidwell (Brentford) wins a free kick in the defensive half.
Foul by Sam Vokes (Burnley).
Corner, Burnley. Conceded by Harlee Dean.
Attempt missed. Konstantin Kerschbaumer (Brentford) right footed shot from outside the box is too high. Assisted by Alan Judge.
Attempt missed. Marvin Sordell (Burnley) right footed shot from the right side of the box misses to the left. Assisted by Sam Vokes with a headed pass.
Substitution, Burnley. Marvin Sordell replaces Lukas Jutkiewicz.
Substitution, Brentford. Jermaine Udumaga replaces Alan McCormack.
Foul by Maxime Colin (Brentford).
Matthew Taylor (Burnley) wins a free kick on the left wing.
Foul by Jake Bidwell (Brentford).
Tendayi Darikwa (Burnley) wins a free kick in the defensive half.
James Tarkowski (Brentford) wins a free kick in the defensive half.
Foul by Lukas Jutkiewicz (Burnley).
Attempt missed. Matthew Taylor (Burnley) left footed shot from outside the box is close, but misses to the right from a direct free kick.
Foul by Konstantin Kerschbaumer (Brentford).
David Jones (Burnley) wins a free kick in the attacking half.