Linfield start life without Warren Feeney with a Big Two showdown against Glentoran at Windsor Park.
Feeney's resignation on Tuesday leaves assistant boss Andy Todd and first-team coach Alfie Wylie in temporary charge of the Premiership pacesetters.
Blues defender Sean Ward is suspended after his dismissal against Cliftonville last weekend.
Glentoran will be aiming to bounce back from a disappointing 2-0 home defeat by Ballinamallard United at the Oval.
"It's a big incentive after Saturday's defeat to go out and put in a performance, put in a shift and take it from there," said Glens manager Eddie Patterson.
"Not many players came out with much credit from the Mallards game, not only from a playing point of view, but also in terms of workrate.
"We are down to the bare bones in terms of injuries and hopefully we'll have a couple of players back for the Linfield match.
"Our big problem at present is creativity from midfield and that's where Ciaran Caldwell comes in - his suspension can't end soon enough."
Linfield are two points clear of champions Crusaders, who have dropped just two points from their last eight league outings.
Stephen Baxter's team entertain a Warrenpoint Town team sitting four points adrift at the bottom.
Cliftonville pair Eamon Seydak and Caoimhin Bonner are suspended for the Stangmore Park encounter with Dungannon Swifts after being sent-off against Linfield.
The Swifts also had two players red-carded last weekend with Douglas Wilson and Jamie Glackin sitting out Saturday's game.
Portadown enjoyed a welcome win at Carrick Rangers last weekend and Ronnie McFall's men host Ballymena United.
Coleraine are just six points off the top and the inform Bannsiders make the trip to Carrick.
Danske Banks Premiership
Saturday, 10 October - 15:00 BST kick-off
Carrick Rangers v Coleraine
Crusaders v Warrenpoint Town
Dungannon Swifts v Cliftonville
Linfield v Glentoran
Portadown v Ballymena Utd