LA Galaxy visit Sporting Kansas City on the final day of the regular Major League Soccer needing a win to guarantee second place in the Western Conference (Sunday, 23:00 GMT).
Steven Gerrard and Robbie Keane's side have already sealed a play-off place, but second spot would mean they would face three rounds rather than four.
Galaxy are the defending champions.
All 10 games have something riding on them, although Frank Lampard's New York City cannot reach the play-offs.
City's rivals New York Red Bulls - for whom Shaun and Bradley Wright-Phillips play - are leading the combined table on goal difference from FC Dallas.
The Supporters' Shield goes to the team who finish top of the overall regular-season table.
Four different teams could overtake Galaxy, who have won three of the last four MLS Cup titles, if they lose to Kansas City, who need a win to seal their own play-off place.