Cliftonville manager Gerard Lyttle believes the League Cup holders will have to be at their best to overcome Glentoran in Wednesday's quarter-final.
"We know it will be a difficult game against the Glens - they always make it hard for us," said Lyttle.
"We've had great success in this competition, we're at home and we'll be aiming to get through to the semis."
Ards host Ballinamallard and Institute face Warrenpoint while Ballymena entertain derby rivals Coleraine.
The Bannsiders are just five points off the top after an unbeaten run of nine games in the Irish Premiership.
"Coleraine will go into the game as favourites," said Sky Blues boss Glenn Ferguson.
"They are in good form and well up the league, they're picking teams off and scoring plenty of goals.
"We have a lot on players out through injuries and suspensions while Matthew Shevlin is with the Northern Ireland U19s.
"Bit we'll try to take the game to Coleraine and secure a place in the last four."
JBE League Cup quarter-finals
Wednesday 18 November - 19:45 GMT
Ards v Ballinamallard Utd
Ballymena Utd v Coleraine
Cliftonville v Glentoran
Institute v Warrenpoint Town
There will be live coverage of the League Cup quarter-finals on Radio Ulster MW