Manchester City goalkeeper Joe Hart may be out for 10 days after suffering a hamstring injury in the midweek Champions League defeat at Juventus.
The England international, 28, is expected to miss two league games and Tuesday's League Cup quarter-final.
"It is not serious but a muscle injury - so it is important to recover well," City boss Manuel Pellegrini said.
Willy Caballero will step in, while on the bench Richard Wright will make a first top-flight nod in nine years.
City are also without the injured Vincent Kompany, Eliaquim Mangala, Pablo Zabaleta and Samir Nasri.
|Forthcoming City fixtures|
|28 November: Southampton, Premier League (home)|
|1 December: Hull, League Cup quarter-final (home)|
|5 December: Stoke, Premier League (away)|
|8 December: B M'gladbach, Champions League (home)|
Argentine Caballero replaced Hart in Turin on Wednesday and will deputise against Southampton at the Etihad on Saturday.
Caballero, 34, has only made one league appearance for City this term, when they were beaten 4-1 by Tottenham at White Hart Lane.
Hart has kept seven Premier League clean sheets this season and Pellegrini said: "We lost Joe in a very good moment but it is what happens.
"I trust a lot in Willy Caballero. I am sure he will have a good performance in these games."