Alvaro Negredo scored a hat-trick as Gary Neville's Valencia thrashed Granada in the Copa del Rey round of 16 first leg.
The ex-Manchester City striker dispossessed a defender before firing them into an early lead and Rodrigo tapped their second into an empty net.
Negredo put Valencia in control of the tie with two second-half penalties.
The 30-year-old, who had appendicitis this season, had scored three goals in his previous 15 games this campaign.
Both goalscorers started for the cup tie, having come on as substitutes in Sunday's 2-2 draw with Real Madrid, Rafael Benitez's last game in charge.
Wednesday's victory was Neville's second as Valencia boss, having beaten Barakaldo 2-0 in the last round.
The second leg of their tie with La Liga strugglers Granada is on Thursday, 14 January.
Earlier on Wednesday, second tier Mirandes drew 1-1 with Deportivo La Coruna in their first leg.
Athletic Bilbao, who lost last year's final to Barcelona, beat Villarreal 3-2.
- 3Nunes Vezo
- 6OrbanBooked at 45mins
- 10ParejoSubstituted forPiattiat 45'minutes
- 18Fuego Martínez
- 15PérezBooked at 26minsSubstituted forZahiboat 64'minutes
- 17RodrigoSubstituted forde Paulat 76'minutes
- 22Mina Lorenzo
- 20de Paul
- 24Domenech Sánchez
- 30Villalba Rodrigo
- 36Latorre Grueso
- 12Doria MacedoBooked at 48mins
- 25Almeida Costa Lopes
- 26Henry Agbo
- 3BiraghiBooked at 44minsSubstituted forMéndez Ortegaat 64'minutesBooked at 75mins
- 23Rochina NaixesSubstituted forMárquez Morenoat 72'minutesBooked at 79mins
- 11SuccessSubstituted forEl-Arabiat 61'minutes
- 2Rodríguez Lombán
- 4Rico Castro
- 8Márquez Moreno
- 17Méndez Ortega
- Jesús Gil Manzano
- Shots on Target