Harland and Wolff Welders will hope to repeat last season's Irish Cup win over Glenavon when the sides meet in the fifth round at Tillysburn on Saturday.
The Lurgan Blues lost 2-0 in the sixth round tie between the sides at the same venue last year.
Linfield host Ballymena United in the tie of the round at Windsor Park.
Blues manager David Healy must again plan without versatile left-sided player Niall Quinn, who is sidelined with a hamstring injury.
United are without central defender Gareth Rodger, whose loan spell from St Johnstone has come to an end.
Glenavon survived a scare in the fifth round last year when they came from two goals down to see off Moyola Park 3-2 but received a boost this week with the news that goalkeeper Jonny Tuffey had been named Northern Ireland Football Writers' Player of the Month for December.
Tuffey conceded only one goal in December, keeping clean sheets against Carrick Rangers, Coleraine and Portadown as the Mourneview Park outfit emerged from the month with 10 Premiership points.
The Welders will hope for more goals from in-form striker Michael McLellan, who has already scored 26 times this season.
Cliftonville have not won the Irish Cup since 1979 and must face Amateur League team Immaculata without forward David McDaid, who could be out for three weeks after sustaining a shoulder injury in the New Year's Day draw with Warrenpoint Town.
"We will be treating Immaculata with the utmost respect. They have come through the leagues and they have an enthusiastic manager and a capable group of players. It will be a fantastic occasion," said Reds manager Gerard Lyttle.
Crues without defensive duo
At Seaview, Crusaders should prove too strong for Rathfriland Rangers despite being without suspended defenders Billy Joe Burns and Colin Coates, while Jordan Owens is also a doubtful starter as he awaits the birth of his child.
Portadown have home advantage over Championship Two outfit Wakehurst, with the Shamrock Park side hoping to go one better than last term when they lost 1-0 to Glentoran in the final following a controversial refereeing decision.
"We still feel a bit aggrieved as to how the final panned out in May but a home draw is all you can ask for in the cup and we will be fired up for the game," said Ports assistant manager Kieran Harding.
"The Irish Cup offers an opportunity to win some silverware and secure a place in European football so we have to be on our guard and play to our capabilities. We must cut out the defensive frailties which cost us dearly against Ballymena last week," he added.
Semi-final defeat motivating Coleraine
Ballinamallard United have acquired ex-Northern Ireland international Ivan Sproule on loan from Linfield as they set out to avenge last week's 1-0 league defeat by Coleraine at Ballycastle Road when the sides meet at the same venue.
"The slate is wiped clean and form goes out the window when it comes to the cup. It's all about who turns up on the day - who starts well and who wants it the most," argued Coleraine manager Oran Kearney.
"We will use the defeat by Ards in the League Cup semi-final as an incentive to kick on and try to progress into the next round of this competition," added the Bannsiders boss.
The Glentoran v Ards and Knockbreda v Annagh Utd matches have been postponed because of waterlogged pitches.
There will be live coverage of the day's action on Sportsound on BBC Radio Ulster from 13:30 GMT on Saturday.
|Tennents Irish Cup fifth round - Saturday 9 January - 15:00 GMT unless stated|
|Banbridge Town||v||Carrick Rangers (13:30)|
|Crumlin Star||v||Oxford U Stars (13:30)|
|Dungannon Swifts||v||Warrenpoint Town|
|H&W Welders||v||Glenavon (13:30)|
|Sport & Leisure Swifts||v||Institute (13:30)|
|Tobermore Utd||v||PSNI (13:30)|