Match ends, Sampdoria 2, Napoli 4.
Serie A leaders Napoli remain top after holding off a spirited Sampdoria side to earn their fifth successive league win.
Maurizio Sarri's side, who are chasing a first Scudetto since 1990, completely controlled the match throughout.
Argentina striker Gonzalo Higuain fired the visitors ahead with his 21st league goal of the season after pouncing on Edgar Barreto's sloppy backpass.
Sampdoria midfielder Barreto then conceded a penalty which allowed Lorenzo Insigne to double Napoli's lead from the spot.
The visitors continued to slice open the home defence regularly without adding a third, allowing Sampdoria to halve the deficit on the verge of half-time when Joaquin Correa stroked in Carlos Carbonero's square pass.
But the hosts' task was made even harder when veteran full-back Mattia Cassani was sent off for a second booking just before the hour.
Within seconds they suffered further punishment, Napoli skipper Marek Hamsik weaving his way through the defence and poking in his fourth goal in four league matches for a 3-1 lead.
Sampdoria again moved back within a goal when Eder headed in Ricardo Alvarez's cross, only for Belgium midfielder Dries Mertens to drill in the fourth for Napoli.
Second-placed Juventus kept pace with the leaders by beating Roma in Turin later on Sunday.
Elsewhere in Serie A
Champions League-chasing Inter Milan were held to a 1-1 home draw as substitute Kevin Lasagna earned 10-man Carpi a late draw.
The striker, who was playing amateur football less than two years ago, scored a stoppage-time equaliser as Inter dropped to fourth.
Roberto Mancini's side were leapfrogged by Fiorentina, who responded to back-to-back defeats with a 2-0 win over Torino.
But, despite goals from Josip Ilicic and Gonzalo Rodriguez, they remain six points adrift of leaders Napoli.
- 5CassaniBooked at 59mins
- 8BarretoSubstituted forÁlvarezat 56'minutes
- 7Lucas MartinsBooked at 45mins
- 10CorreaSubstituted forIvanat 80'minutes
- 99CassanoSubstituted forPires Ribeiroat 65'minutes
- 11Pires Ribeiro
- 13Miguel Pereira
- 31GhoulamSubstituted forStrinicat 71'minutes
- 8JorginhoBooked at 13mins
- 7CallejónSubstituted forEl Kaddouriat 84'minutes
- 24InsigneSubstituted forMertensat 75'minutes
- 19López Silva
- 22Vasconcellos Ferreira
- 77El Kaddouri
- Daniele Orsato
- Shots on Target
Second Half ends, Sampdoria 2, Napoli 4.
Attempt missed. Omar El Kaddouri (Napoli) right footed shot from the centre of the box is high and wide to the right. Assisted by Jorginho.
Foul by Kalidou Koulibaly (Napoli).
Éder (Sampdoria) wins a free kick in the attacking half.
Attempt saved. Gonzalo Higuaín (Napoli) right footed shot from the centre of the box is saved in the centre of the goal. Assisted by Dries Mertens.
Omar El Kaddouri (Napoli) wins a free kick in the defensive half.
Foul by Éder (Sampdoria).
Offside, Napoli. Jorginho tries a through ball, but Dries Mertens is caught offside.
Attempt missed. Éder (Sampdoria) right footed shot from more than 35 yards is close, but misses to the left.
Attempt blocked. Gonzalo Higuaín (Napoli) right footed shot from the centre of the box is blocked.
Attempt saved. Omar El Kaddouri (Napoli) right footed shot from the centre of the box is saved in the bottom right corner. Assisted by Allan.
Substitution, Napoli. Omar El Kaddouri replaces José Callejón.
Dries Mertens (Napoli) wins a free kick on the left wing.
Foul by Carlos Carbonero (Sampdoria).
Substitution, Sampdoria. David Ivan replaces Joaquin Correa.
Goal! Sampdoria 2, Napoli 4. Dries Mertens (Napoli) left footed shot from the left side of the box to the bottom right corner. Assisted by José Callejón.
Attempt missed. Gonzalo Higuaín (Napoli) right footed shot from the right side of the box is too high. Assisted by Jorginho.
Attempt missed. Marek Hamsik (Napoli) right footed shot from the centre of the box misses to the right.
Substitution, Napoli. Dries Mertens replaces Lorenzo Insigne.