Boss Gareth Ainsworth says if Wycombe replicate their FA Cup performances against Aston Villa in League Two, they will "win a lot more than we lose".
The Chairboys lost their third-round replay at Villa Park 2-0 on Tuesday.
"I've said to the boys 'Some of you will get to this level'. I'm confident I've got a couple of players who will get to the Championship, Premier League," said Ainsworth.
"The problem will be holding onto some of them now."
He told BBC Three Counties Radio: "I thought the two centre-halves were fantastic, Jason McCarthy had a good game at right-back, the two old ones up front ran their socks off, Matt Bloomfield has a new lease of life - to a man I'm very, very proud.
"Back to reality now. On Thursday we'll be training on how to beat Leyton Orient which will be a tough game with no manager and the unknown coming and we'll need some energy back in these legs now."
Goals from Ciaran Clark and Idrissa Gueye gave the Premier League's bottom side victory, despite them being on the back foot for much of the first half against their fourth-tier opponents.
Ainsworth also praised the performance of centre-back Aaron Pierre, who helped keep out Villa for 75 minutes.
"He's going to turn heads," he said. "He's not the complete defender but he's got all the tools in the bag, it's just getting them in the right order.
"He wins headers, is a threat in the opposition box, he's the quickest centre-half I've ever seen, he's strong, he's got everything. He needs to still work on certain things but will attract some attention.
"But in Anthony Stewart next to him you've got two centre-halves you'd hang your hat on all day - but I don't like singling people out, we win and lose together."