Match ends, Shrewsbury Town 1, Southend United 2.
Loanee Stephen Hendrie's late winner helped Southend beat Shrewsbury Town to climb to seventh place in League One.
Will Atkinson's 25-yard shot put the visitors ahead, before Andy Mangan equalised for Shrewsbury from close range just after the break.
Southend's Michael Timlin was dismissed for a second yellow with 25 minutes remaining for a foul on Jack Grimmer.
But the 10 men won it when, from 12 yards, Hendrie smashed in on-loan Norwich debutant Jamar Loza's cross.
Southend move level on points with sixth-placed Millwall, while Shrewsbury remain a point clear of the relegation zone in 20th.
Town's seven straight home league game without a win, during which they have lost five times, came just three days after knocking Championship side Sheffield Wednesday out of the FA Cup at the Greenhous Meadow.
Shrewsbury Town manager Micky Mellon told BBC Radio Shropshire:
"It is probably the best we have been at home for a while. We played some good football, but we just didn't take our chances. We lacked the end product.
"I would have been disappointed with a point let alone a loss. Then we switched off in defence and, when you do that, you end up on the wrong end of the result.
"Apart from the mistake for their goal I can't really criticize the lads' performance. It is a sore one to take. It was a good performance but we got punished for mistakes."
- 4WhitbreadSubstituted forVernonat 81'minutes
- 38WallaceSubstituted forWhalleyat 33'minutes
- 24O'NeillBooked at 90mins
- 10PayneSubstituted forMcQueenat 68'minutesBooked at 90mins
- 16HuntSubstituted forTimlinat 50'minutesBooked at 65mins
- 9MooneySubstituted forLozaat 67'minutes
- Chris Sarginson
- Shots on Target
Second Half ends, Shrewsbury Town 1, Southend United 2.
Sam McQueen (Southend United) is shown the yellow card.
Hand ball by Stephen Hendrie (Southend United).
Luke O'Neill (Southend United) is shown the yellow card.
Junior Brown (Shrewsbury Town) wins a free kick in the defensive half.
Foul by Luke O'Neill (Southend United).
Corner, Southend United. Conceded by Nathaniel Knight-Percival.
Foul by Jean-Louis Akpa-Akpro (Shrewsbury Town).
Adam Thompson (Southend United) wins a free kick in the defensive half.
Corner, Shrewsbury Town. Conceded by Will Atkinson.
Attempt missed. Richard Wellens (Shrewsbury Town) right footed shot from outside the box is close, but misses to the right.
(Shrewsbury Town) wins a free kick in the attacking half.
Foul by Jamar Loza (Southend United).
Corner, Shrewsbury Town. Conceded by Stephen Hendrie.
Richard Wellens (Shrewsbury Town) wins a free kick in the attacking half.
Foul by Cian Bolger (Southend United).
Attempt missed. Ian Black (Shrewsbury Town) right footed shot from outside the box is just a bit too high.
Substitution, Shrewsbury Town. Scott Vernon replaces Zak Whitbread.
Jean-Louis Akpa-Akpro (Shrewsbury Town) wins a free kick in the defensive half.