Match ends, PSV Eindhoven 0, Atlético de Madrid 0.
PSV Eindhoven's last-16 Champions League tie with Atletico Madrid is finely poised after the hosts survived the last 22 minutes with 10 men.
Atletico should have been ahead at the interval, Jeffrey Bruma clearing Luciano Vietto's attempt off the line.
Antoine Griezmann was then denied by a fine save from PSV keeper Jeroen Zoet after springing the offside trap.
Dutch champions PSV went close through Davy Propper before Gaston Pereiro was sent off in the 68th minute.
Uruguay-born forward Pereiro, who had already been booked, was ordered off after jumping into countryman Diego Godin.
Atletico Madrid, the 2014 runners-up, will start as favourites to advance to the quarter-finals when the two teams meet in the second leg at the Vicente Calderon on 15 March.
Atletico's scoring problems mount for Simeone
Atletico remain unbeaten away from home in the Champions League this season.
In addition, Diego Simeone's side have now secured an impressive 12th clean sheet in 16 Champions League outings.
However, their problems are increasing at the other end of the pitch and they have now managed just seven goals in eight games.
Substitute Fernando Torres injected some urgency into their play when the former Liverpool forward came on for the final half an hour.
Yet Griezmann's failure to score when clean through proved costly, while Koke also spurned a chance after PSV's suspect defence was sliced wide open.
The Dutch leaders had beaten Manchester United, Wolfsburg and CSKA Moscow at home in the group stages.
Yet Phillip Cocu's side struggled to pose Atletico's defence problems, Propper forcing Jan Oblak into a rare serious save after pinball inside the visitors' defence.
PSV Eindhoven boss Phillip Cocu: "I am very satisfied with this result. I said beforehand that if we could keep a clean sheet at home it would put us in a good position for the second leg."
Atletico Madrid boss Diego Simeone: "Goals will come. They're a tough opponent. I'm relaxed with the fact we have the game at home in the second leg. The only thing we missed was scoring a goal.
"From the start of the game we pressed them, played in their half and created chances. In the second half we controlled the game and Oblak didn't have a save to make, so I am very happy with the team."
The stats you need to know
- PSV failed to score in a Champions League home match for the first time since 16 September 2008
- The Dutch champions remain unbeaten in four consecutive Champions League matches for the first time since 2006
- Atletico kept a clean sheet for the fifth time in Europe this season
- Gaston Pereiro became the second PSV player to receive a red card in the Champions League season after Santiago Arias
While Atletico Madrid return to Spain to prepare for Saturday's derby against Real Madrid at the Bernabeu Stadium (15:00 GMT), PSV Eindhoven will be looking to make it nine league wins in a row when they entertain Den Haag on the same day (18:45 GMT).
- 18GuardadoSubstituted forHendrixat 75'minutes
- 28van Ginkel
- 11NarsinghSubstituted forIsimat-Mirinat 65'minutes
- 7PereiroBooked at 68mins
- 19LocadiaSubstituted forLestienneat 86'minutes
- 20Torres Belén
- 15SavicBooked at 22mins
- 3Filipe Luís
- 14Fernández Arenas
- 17SaúlSubstituted forCorreaat 74'minutes
- 10Torres Muñoz
- 23ViettoSubstituted forTorresat 61'minutes
- 1Moyá Rumbo
- 24Giménez de Vargas
- Daniele Orsato
- Shots on Target
Second Half ends, PSV Eindhoven 0, Atlético de Madrid 0.
Foul by Antoine Griezmann (Atlético de Madrid).
Jeroen Zoet (PSV Eindhoven) wins a free kick in the defensive half.
Attempt missed. Ángel Correa (Atlético de Madrid) right footed shot from the left side of the box misses to the right. Assisted by Antoine Griezmann.
Attempt missed. Maxime Lestienne (PSV Eindhoven) right footed shot from a difficult angle on the right is too high. Assisted by Jorrit Hendrix with a cross.
Hand ball by Gabi (Atlético de Madrid).
Substitution, PSV Eindhoven. Maxime Lestienne replaces Jürgen Locadia.
Filipe Luis (Atlético de Madrid) wins a free kick in the defensive half.
Foul by Jürgen Locadia (PSV Eindhoven).
Attempt saved. Antoine Griezmann (Atlético de Madrid) header from the centre of the box is saved in the top centre of the goal. Assisted by Gabi with a cross.
Corner, Atlético de Madrid. Conceded by Jetro Willems.
Attempt blocked. Ángel Correa (Atlético de Madrid) right footed shot from the right side of the box is blocked. Assisted by Juanfran.
Corner, Atlético de Madrid. Conceded by Jeffrey Bruma.
Attempt blocked. Fernando Torres (Atlético de Madrid) right footed shot from the right side of the box is blocked. Assisted by Antoine Griezmann.
Corner, Atlético de Madrid. Conceded by Héctor Moreno.
Substitution, PSV Eindhoven. Jorrit Hendrix replaces Andrés Guardado.
Substitution, Atlético de Madrid. Ángel Correa replaces Saúl Ñíguez.
Corner, Atlético de Madrid. Conceded by Santiago Arias.
Attempt missed. Fernando Torres (Atlético de Madrid) right footed shot from the centre of the box is too high. Assisted by Juanfran with a cross.