Match ends, Valencia 2, Athletic Club 1.
Under-fire Valencia coach Gary Neville was sent to the stands as his team were knocked out of the Europa League on away goals by Athletic Bilbao.
The hosts levelled the aggregate score at 1-1 through Santi Mina and went ahead through a superb Santos header.
But Aritz Aduriz scored a crucial late goal following a Raul Garcia flick.
An incensed Neville was punished for protesting against an apparent handball in the build-up to the goal and replays suggest his claims were legitimate.
The ball did appear to make contact with Oscar de Marcos' arm before it fell to Garcia, whose brilliant touch found Aduriz to score his 31st goal of the season.
The former Manchester United defender, 41, was already under intense scrutiny after a run of three straight defeats which included a 1-0 league loss to bottom-of-the-table Levante on Sunday.
But Valencia were the better side against a team who are six places above them in the league and were on a five-game winning streak in all competitions prior to the match.
Paco Alcacer had a chance to rescue his team in the dying minute only for Iago Herrerin to save from point-blank range, while a Parejo free-kick in added time was a fraction wide.
Defending champions Sevilla progress
Sevilla, winners for the past two years, became the first team to reach the Europa League last eight in three consecutive seasons.
The Spaniards extended their unbeaten home run to 17 in all competitions with a 3-0 defeat of a Basel team who had earned a 0-0 draw in the first leg.
Elsewhere, Villarreal - enjoying a 2-0 first-leg lead - reached the last eight after holding Bayer Leverkusen to a goalless draw in Germany.
Sparta Prague beat Lazio 3-0 in Rome with goals from Borek Dockal, Ladislav Krejci and Lukas Julis boosting the aggregate score to 4-1.
Sporting Braga (agg 4-2) and Shakhtar Donetsk (agg 4-1) also progressed, knocking out Fenerbache and Anderlecht respectively.
- 3Nunes VezoBooked at 83mins
- 14Gayá Peña
- 12Barbosa da Silva
- 18Fuego MartínezBooked at 42minsSubstituted forParejoat 68'minutes
- 21André GomesBooked at 74minsSubstituted forAlcácerat 83'minutes
- 17RodrigoSubstituted forFeghouliat 75'minutes
- 22Mina LorenzoBooked at 40mins
- 24Domenech Sánchez
- 44Soler Barragán
- 13Herrerín Buisán
- 10De Marcos Arana
- 16Etxeita Gorritxategi
- 4LaporteBooked at 77mins
- 24Balenziaga OruesagastiSubstituted forLekue Martínezat 75'minutes
- 6San José
- 7Etxebarria Urkiaga
- 27Merino ZuloagaSubstituted forIturraspe Derteanoat 75'minutes
- 22Garcia EscuderoBooked at 45mins
- 19Muniain GoñiSubstituted forSusaetaat 25'minutes
- 1Iraizoz Moreno
- 2Bóveda Altube
- 5Eraso Goñi
- 8Iturraspe Derteano
- 17Rico Moreno
- 30Lekue Martínez
- Daniele Orsato
- Shots on Target
Second Half ends, Valencia 2, Athletic Club 1.
Attempt missed. Daniel Parejo (Valencia) right footed shot from outside the box is close, but misses to the left from a direct free kick.
Foul by San José (Athletic Club).
Santi Mina (Valencia) wins a free kick in the attacking half.
Attempt missed. Íñigo Lekue (Athletic Club) right footed shot from the centre of the box misses to the left. Assisted by Aduriz following a fast break.
Offside, Valencia. Daniel Parejo tries a through ball, but Shkodran Mustafi is caught offside.
Foul by Aymeric Laporte (Athletic Club).
Álvaro Negredo (Valencia) wins a free kick on the right wing.
Offside, Valencia. Álvaro Negredo tries a through ball, but Paco Alcácer is caught offside.
Aymeric Laporte (Athletic Club) wins a free kick in the defensive half.
Foul by Álvaro Negredo (Valencia).
Attempt saved. Paco Alcácer (Valencia) header from the centre of the box is saved in the centre of the goal. Assisted by Álvaro Negredo with a headed pass.
Substitution, Valencia. Paco Alcácer replaces André Gomes.
Rúben Vezo (Valencia) is shown the yellow card for a bad foul.
Markel Susaeta (Athletic Club) wins a free kick in the defensive half.
Foul by Rúben Vezo (Valencia).
Delay over. They are ready to continue.
Delay in match Aduriz (Athletic Club) because of an injury.
Aduriz (Athletic Club) wins a free kick in the attacking half.