The Tyne-Wear and Manchester derbies feature among four Premier League games on Sunday with huge importance for the top and bottom of the table.
Second-placed Tottenham will aim to close the gap to leaders Leicester to five points when they host Bournemouth.
Both Sunderland and Newcastle are in the relegation zone after Norwich's win at West Brom on Saturday, with the Black Cats going to St James' Park one point above the 19th-placed Magpies.
Manchester United will be hoping to close the gap to fourth-placed Manchester City to a single point at the Etihad Stadium, while a three-goal win would take them above West Ham into fifth.
Southampton host Liverpool with the sides eighth and ninth respectively in the table.