New Morocco coach Herve Renard begins his quest for a record-equalling third Africa Cup of Nations as qualifying for the 2017 tournament resumes this week.
The Frenchman will over see back-to-back qualifiers against Cape Verde, the top-ranked African team.
A seven-day, 50-match schedule starts on Wednesday and the co-Group F leaders meet in Praia Saturday and in Marrakech Tuesday in key matches as only mini-league winners are guaranteed places at the finals in Gabon.
Both countries beat Sao Tome e Principe convincingly and Libya narrowly in previous group games, with Cape Verde topping the table on goal difference.
Renard, a 47-year-old who succeeded Badou Zaki last month after indifferent Moroccan performances, guided no-hopers Zambia to 2012 glory and repeated the feat with perennial underachievers Ivory Coast last year.
Hassan Shehata coached Egypt to three consecutive titles between 2006 and 2010, but only Renard has won the Nations Cup with different countries.
His successes in Africa contrast with failures in France. He could not prevent Sochaux being relegated and a second Ligue 1 stint ended this season with Lille sacking him.
Given that Morocco are ranked only 19th in Africa, Renard has been set a tough target of at least reaching the 2017 Nations Cup semi-finals by his new employers.
And while some pundits remain sceptical as to whether Cape Verde are the strongest African national football team, they are chasing a third consecutive finals appearance.
Like Morocco, Cape Verde will have a new coach with local Felisberto 'Beto' Cardoso succeeding Portuguese Rui Aguas, who quit after not being paid for seven months.
Cape Verdean football officials said the salary was supposed to be paid by Portugal under a development and co-operation agreement between the countries.
Former assistant coach Cardoso will rely heavily on Djaniny and Heldon for goals while Moroccan sharpshooter Youssef El Arabi bagged a brace in Spain at the weekend.
Renard has successfully persuaded France-born Lille midfielder Sofiane Boufal to play for the country where his parents were born.
Other high-profile showdowns involve Nigeria and Egypt in Group G and Cameroon and South Africa in Group M.
Nigeria, who have home advantage first, are another team with a new coach as Samson Siasia took over when Sunday Oliseh quit following a social media rant against his critics.
Those called up for the Super Eagles include 19-year-old Alex Iwobi, whose first English Premier League start for Arsenal was crowned by the second goal in a 2-0 weekend win at Everton.
The youngster suffered a scare when he fell ill and was taken to hospital in Abuja on Tuesday but he has made a recovery and will be fit to play.
"Had The Maddest Food Poisoning But I Am Good Now & Feeling Ready For The Egyptian Match," Iwobi Tweeted.
Argentina-born Egypt coach Hector Cuper has recalled 43-year-old Nations Cup-winning goalkeeper Essam El Hadary after an injury ruled out first choice Sherif Ekramy.
The squad also includes in-form Roma striker Mohamed Salah and mid-season Arsenal recruit Mohamed Elneny.
Egypt, whose three titles in a row were followed by failures to qualify for the last three tournaments, beat Tanzania and Chad convincingly to lead Nigeria by two points.
South Africa coach Ephraim 'Shakes' Mashaba has come under media fire for picking out-of-favour players like Bournemouth striker Tokelo Rantie for must-win games against Cameroon.
Bafana Bafana were held by Gambia and lost to Mauritania, leaving them bottom of the table and five points adrift of the Indomitable Lions.
New Belgium-born Cameroon coach Hugo Broos has recalled Alex Song, whose last appearance ended prematurely with a 2014 World Cup red card against Croatia.
Another African in the running to play for the first time since the last World Cup is United States-based Ghana goalkeeper Adam Kwarasey.
The Group H leaders will lack injured midfielder Andre Ayew against bottom-of-the-table Mozambique, but younger brother Jordan is among the strikers chosen by coach Avram Grant.
Home and away fixtures against lowly-ranked Sudan offer defending champions Ivory Coast a realistic chance to win in Abidjan and Khartoum and build a four-point Group I lead.