Reading are to release Hal Robson-Kanu, Anton Ferdinand and Simon Cox after their current contracts expired.
Striker Robson-Kanu, 27, who is expected to be part of Wales' squad for the European Championships, has spent seven seasons with the club.
Former West Ham and Sunderland defender Ferdinand, 31, has suffered with injuries in two seasons at Reading.
Academy graduate Cox, 29, who rejoined the club in summer 2014, has struggled for goals in the last two campaigns.
The Championship club have also confirmed that six loan players who represented them this season have all returned to their parent clubs.
Defender Andrew Taylor, midfielders Ola John and Alex Fernandez and striker Matej Vydra follow the departures of Chelsea pair Michael Hector and Lucas Piazon, who left the club last month.