Real Madrid centre-back Raphael Varane is a major doubt for the Champions League final against Atletico Madrid on Saturday because of injury.
The club confirmed the 23-year-old has "a grade two injury in the left thigh muscle" - but did not specify a timeline for his return.
But Spanish media report that he will miss the San Siro final, and is a doubt for France's first Euro 2016 match.
Les Bleus face Romania in the tournament opener on Friday, 10 June.
France have called Sevilla defender Adil Rami into their training squad.