Brazil's Kaka is out of the Copa America with a muscle injury and will be replaced by Paulo Henrique Ganso.
The former AC Milan and Real Madrid midfielder, who now plays for Orlando City in Major League Soccer, was a late replacement for Douglas Costa.
Kaka, 34, is the fifth player to withdraw from the squad and is expected to be out for about three weeks.
The 100th anniversary Copa America starts in the United States on Friday, with Brazil's first game on Saturday.
Their campaign begins against Ecuador, before they face Haiti on 9 June and then Peru on 13 June.
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