Burnley midfielder Jack Cork has been called up to the England squad for the friendlies against Germany and Brazil.
Raheem Sterling, Fabian Delph and Jordan Henderson pulled out of Gareth Southgate's squad on Tuesday after Tottenham trio Harry Kane, Dele Alli and Harry Winks also withdrew.
The uncapped Cork, 28, joined Burnley from Swansea in July and has played every minute of their Premier League campaign to date.
"I'm really, really happy," he said.
"We've had a good start to the season and you're probably not going to get many better opportunities to be in the England squad, because we are doing so well.
"Four or five of the lads in the Burnley squad probably could have got in at the same time as me, so I feel lucky that I've been given the chance."
- World Cup play-offs: what you need to know
- 'I've a lot of belief that we can do it' - NI captain Davis bullish for Swiss play-off
Cork has represented England at every level from under-16 to under-21 and also represented Great Britain at the 2012 London Olympics while playing for Southampton.
Burnley manager Sean Dyche said: "It's great for him and a deserved call-up."
Chelsea defender Gary Cahill has also joined up with England, having been assessed by his club's medical team amid injury concerns.
England host Germany at Wembley on Friday and then play Brazil at the same venue on 14 November.
Manchester City winger Sterling and club-mate Delph, who is a midfielder but has been playing at left-back, were both involved in their side's 3-1 win over Arsenal on Sunday.
Sterling came off after 78 minutes, while Delph played the whole game but appeared to pick up an injury in the closing stages.
Liverpool midfielder Henderson missed his team's 4-1 victory at West Ham on Saturday with a thigh injury and, after being assessed by his club, has stayed on Merseyside.
West Brom midfielder Jake Livermore was called up as a replacement following the withdrawal of Kane and Winks.
Striker Kane has a knee injury while midfielder Winks has an ankle problem. The pair had treatment during the 1-0 win over Crystal Palace on Sunday.
Their Spurs team-mate Alli had already withdrawn from the original squad - and on Monday, England called up Everton defender Michael Keane to replace him.
Goalkeepers: Jack Butland (Stoke City), Joe Hart (West Ham - loan from Manchester City), Jordan Pickford (Everton).
Defenders: Ryan Bertrand (Southampton), Gary Cahill (Chelsea), Joe Gomez (Liverpool), Phil Jones (Manchester United), Michael Keane (Everton), Harry Maguire (Leicester), Danny Rose (Tottenham), John Stones (Manchester City), Kieran Trippier (Tottenham), Kyle Walker (Manchester City).
Midfielders: Eric Dier (Tottenham), Jesse Lingard (Manchester United), Jake Livermore (West Brom), Ruben Loftus-Cheek (Crystal Palace - loan from Chelsea), Ashley Young (Manchester United), Jack Cork (Burnley).
Forwards: Tammy Abraham (Swansea - loan from Chelsea), Marcus Rashford (Manchester United), Jamie Vardy (Leicester).