Match ends, Stoke City 1, Tottenham Hotspur 2.
Mauricio Pochettino says it will be "fantastic" for Tottenham's new stadium to stage Champions League football in its first season after Christian Eriksen's double saw them beat Stoke.
Spurs took a big step towards securing a top-four finish with victory at the relegation-threatened Potters - their sixth successive Premier League win.
The north London side are level on points with third-placed Liverpool and 11 ahead of fifth-placed Chelsea, who host West Ham on Sunday.
Spurs, who are using Wembley for home games this season, are due to move to their new ground for 2018-19, and manager Pochettino said: "To have the opportunity to play in the Champions League in the new stadium will be a fantastic achievement.
"For us it would be a massive achievement to finish top four for a third time."
Stoke frustrated their opponents before Eriksen fired Spurs into the lead from inside the penalty area after Dele Alli's pass.
Mame Biram Diouf equalised after a mistake by keeper Hugo Lloris, whose attempted clearance cannoned off the Stoke striker and fell kindly for Diouf to roll the ball into the net.
In an entertaining match, Eriksen scored the winner from a free-kick before Xherdan Shaqiri was denied a late equaliser when his free-kick hit the bar.
Kane claims winner on return to starting line-up
Although Tottenham were far from their best, this was another positive day for Pochettino as Harry Kane returned to the starting line-up after a recovering from a damaged ankle.
The England striker was quiet by his usual standards before claiming he got the faintest of touches to Eriksen's free-kick for the winning goal.
"It was my goal, it flicked off my shoulder and went in," he said after the game.
However, the Premier League tweeted that the goal had been awarded to Eriksen after a review by the league's Match Centre.
In the end, all that mattered for Pochettino is that his side had secured three more points at a venue where both Arsenal and Manchester United have tripped up this season.
"After his injury, to play 90 minutes today is going to help Harry," added Pochettino.
- Relive the action from Stoke v Tottenham
- Pochettino's milestone - Saturday's best Premier League stats
Another hard luck story for Stoke
For the second successive weekend Stoke produced a battling performance but once again emerged with no reward.
They worked hard at Arsenal before conceding three late goals and this was another hard luck tale to add to the collection.
Paul Lambert's side limited one of the Premier League's form teams to just one serious chance in the first half, Jack Butland producing an excellent save to deny Son Heung-min.
Diouf should have scored two goals before Eriksen broke the deadlock while Shaqiri was frustrated by the bar as Spurs led 2-1.
Stoke had started the day three points from safety. They are now four points from 17th place with five games remaining, including a trip to Liverpool on 28 April.
"Two weeks in a row we come away with nothing," Lambert told BBC Sport.
"The effort and commitment I can not ask more of, we are just not getting the breaks. If they played like that at the beginning of season we would not be in position we are in."
Stoke desperately need a win from somewhere - not another hard luck story.
"I think we have to win at least three games now," added Lambert. "As long as belief and fight is there, we are in with a fighting chance."
Man of the match - Christian Eriksen (Tottenham)
Kane or Eriksen? Whose goal was it?
Tottenham boss Mauricio Pochettino: "It doesn't matter if it was Christian or Harry. It's the three points that are the most important for us."
Christian Eriksen: "Harry celebrated like it was his goal so I will have to take his word for it."
Premier League on Twitter: After review, the Premier League Match Centre has awarded Spurs' second goal to Christian Eriksen.
Played 200, won 103 - the stats
- Mauricio Pochettino took charge of his 200th Premier League game (W103 D53 L44); the first non-European manager to reach the landmark in the competition.
- Mame Biram Diouf has scored as many Premier League goals in 2017-18 (6) as he did in his previous two campaigns combined.
- Spurs have won more Premier League away games at Stoke than any other team (7).
- Christian Eriksen scored a brace against Stoke, taking his tally to 10 Premier League goals this season - his joint-best return in a single campaign (also 10 in 2014-15).
- Dele Alli has been directly involved in six goals in his five Premier League appearances against Stoke (four goals, two assists).
- Alli has provided more league assists this season than in any other campaign (10).
Stoke have nine days to recover before they face fellow strugglers West Ham at London Stadium on Monday, 16 April (20:00 BST). Tottenham entertain Manchester City at Wembley in a fourth-versus-first game next Saturday (19:45 BST).
- 8JohnsonBooked at 71minsSubstituted forCrouchat 78'minutes
- 15Martins IndiBooked at 90mins
- 3PietersBooked at 32mins
- 2BauerSubstituted forZoumaat 90+5'minutes
- 27B NdiayeBooked at 90mins
- 32SobhiSubstituted forCampbellat 69'minutes
- 24AurierBooked at 79mins
- 6D Sánchez
- 3RoseBooked at 90mins
- 12WanyamaSubstituted forDierat 82'minutes
- 20AlliSubstituted forSissokoat 90'minutes
- 7Son Heung-MinSubstituted forLamelaat 67'minutes
- 10KaneBooked at 90mins
- 27Lucas Moura
- Graham Scott
- Shots on Target
Second Half ends, Stoke City 1, Tottenham Hotspur 2.
Danny Rose (Tottenham Hotspur) is shown the yellow card.
Badou Ndiaye (Stoke City) is shown the yellow card.
Attempt saved. Ryan Shawcross (Stoke City) header from the centre of the box is saved in the bottom right corner. Assisted by Joe Allen with a cross.
Substitution, Stoke City. Kurt Zouma replaces Moritz Bauer.
Attempt missed. Eric Dier (Tottenham Hotspur) right footed shot from outside the box is too high. Assisted by Moussa Sissoko.
Harry Kane (Tottenham Hotspur) is shown the yellow card.
Foul by Harry Kane (Tottenham Hotspur).
Ryan Shawcross (Stoke City) wins a free kick in the defensive half.
Attempt saved. Joe Allen (Stoke City) right footed shot from the centre of the box is saved in the bottom left corner. Assisted by Moritz Bauer with a cross.
Bruno Martins Indi (Stoke City) is shown the yellow card for a bad foul.
Attempt blocked. Harry Kane (Tottenham Hotspur) left footed shot from the centre of the box is blocked. Assisted by Moussa Sissoko.
Harry Kane (Tottenham Hotspur) wins a free kick in the attacking half.
Foul by Bruno Martins Indi (Stoke City).
Substitution, Tottenham Hotspur. Moussa Sissoko replaces Dele Alli.
Foul by Dele Alli (Tottenham Hotspur).
Xherdan Shaqiri (Stoke City) wins a free kick on the right wing.
Attempt missed. Ryan Shawcross (Stoke City) header from the left side of the six yard box misses to the left. Assisted by Xherdan Shaqiri with a cross following a corner.
Corner, Stoke City. Conceded by Mousa Dembélé.