Arsenal have been drawn against north London rivals Tottenham Hotspur in the Carabao Cup quarter-finals.
The Gunners, last season's beaten finalists, will host their neighbours at Emirates Stadium during the week starting 17 December.
League One Burton Albion, the lowest-ranked team left in the competition, go to Championship side Middlesbrough.
Chelsea host Bournemouth, while Leicester or Southampton will play holders Manchester City.
The Foxes' tie against the Saints at King Power Stadium has been rearranged for 27 November.
The match, originally scheduled to be played on Tuesday, was postponed following the death of Leicester owner Vichai Srivaddhanaprabha in a helicopter crash.
Arsenal and Spurs will meet twice at the Emirates in little over a fortnight as the teams also play in the Premier League on 2 December.
Arsenal v Tottenham
Leicester/Southampton v Manchester City
Middlesbrough v Burton
Chelsea v Bournemouth