World number one Luke Donald and number two Rory McIlroy will tee-off against a strong field at the BMW PGA Championship at Wentworth on 24 May.
The line-up at the Surrey course boasts 14 major champions, including Ireland's Padraig Harrington, Spaniard Jose Maria Olazabal and South African Ernie Els.
Donald beat Lee Westwood in a play-off to win in 2011, a victory which saw him lead the rankings for the first time.
The event is only one of two Tour events taking place in England in 2012.
The Open Championship at Royal Lytham & St Annes in July is the other English event.
England's Donald and Northern Ireland's McIlroy have swapped places at the top of the rankings four times in 2012, with the Englishman moving back to number one after finishing third in the Zurich Classic of New Orleans in April.
World number three Westwood will also compete at Wentworth, alongside British major winners Darren Clarke, Graeme McDowell and Paul Lawrie.
The other major champions competing at the event will be German Martin Kaymer, South Africans Retief Goosen and Charl Schwartzel, New Zealand's Michael Campbell, Mike Weir from Canada and Americans Shaun Micheel and Rich Beem.