Tony McCoy rode Synchronised to victory in the Lexus Chase at Leopardstown in the Republic of Ireland.
The Jonjo O'Neill-trained horse finished ahead of Rubi Light and favourite Quito De La Roque, ridden by Davy Russell.
McCoy, the 16-time champion jump jockey, previously won the race in 2008 on Exotic Dancer.
Synchronised was originally due to defend the Welsh National on Tuesday, before being re-routed to Leopardstown.
The eight-year-old tracked runner-up Rubi Light and third placed Quito De La Roque into the home straight and swept clear before a fine leap at the last fence sealed victory.
Bookmakers Stan James now make the winner a 12-1 chance for the Cheltenham Gold Cup, while Sky Bet introduced him to their market at 14s.
Lexus Chase (Leopardstown)
1. Synchronised (AP McCoy)
2. Rubi Light (AE Lynch)
3. Quito De La Roque (DN Russell)