Trainer Venetia Williams enjoyed four winners across two meetings at combined odds of 549-1 on Saturday.
A treble at Sandown with Saroque (3-1), Aachen (6-4) and Relax (9-1) was complemented by victory for Emperor's Court (9-2) at Ffos Las.
"I'm thrilled with them all," said Williams, who trained 100-1 shot Mon Mome to win the 2009 Grand National.
Meanwhile, Oscar Whisky claimed the 16th win of his career in the Scilly Isles Novices' Chase at Sandown.
Jockey Barry Geraghty had to be patient with the 1-6 favourite, who made jumping errors in the heavy ground before prevailing by nine lengths from Manyriverstocross.
Trainer Nicky Henderson said his winner needed the run ahead of next month's Cheltenham Festival.
Saphir Du Rheu, trained by Paul Nicholls with nephew Harry Derham on board, won the Welsh Champion Hurdle at Ffos Las.