The 49ers are one of just two undefeated teams left in the NFL, while the Redskins have only beaten the lowly Dolphins this season. The hosts have an interim coach after sacking Jay Gruden and who should be leading the opposition but Kyle Shanahan – who worked in Washington with his dad Mike before both were sacked. Revenge will be sweet today.
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Catch him if you can!
Josh Jacobs weaves powers down the field in a blistering 42-yard run.
Just a note that the Packers have allowed almost as many rushing yards on this first drive as they did all last week versus the Detroit Lions.
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Two top-10 rookie quarterbacks clash in New York - for just the eighth time in 49 years. No.1 overall pick in the draft, Kyler Murray of the Cardinals, faces sixth-pick Daniel Jones of the Giants. Both have started well and against two iffy defences today they could both put on a real show.
The Rams spent big to bring cornerback Jalen Ramsey in from the Jacksonville Jaguars, and surprise, surprise he's over his 'back injury' and can make his debut tonight - where he'll have to cover Falcons star Julio Jones! Here's why the Rams went all-out to get him.
Under way in the 6pm games!
Let's do this!
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Two-time Super Bowl winnerCopyright: Getty Images
I am going to go with the Minnesota Vikings here. The Detroit Lions are playing really, really well as evidenced by the game they should not have lost last week.
It's not a home-field advantage if you are playing in Detroit. The Minnesota Vikings - look what they have done over the last few weeks, I think they are back.
On The NFL Show Osi Umenyiora, Jason Bell and Mark Chapman discuss the San Francisco 49ers' impressive defensive performance against the Los Angeles Rams last week.
Watch: The NFL Show on BBC iPlayer now.
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Buffalo Bills v Miami Dolphins (18:00 BST)
Cincinnati Bengals v Jacksonville Jaguars (18:00 BST)
Detroit Lions v Minnesota Vikings (18:00 BST)
Green Bay Packers v Oakland Raiders (18:00 BST)
Atlanta Falcons v Los Angeles Rams (18:00 BST)
Indianapolis Colts v Houston Texans (18:00 BST)
Washington Redskins v San Francisco 49ers (18:00 BST)
New York Giants v Arizona Cardinals (18:00 BST)
Tennessee Titans v Los Angeles Chargers (21:05 BST)
Chicago Bears v New Orleans Saints (21:25 BST)
Seattle Seahawks v Baltimore Ravens (21:25 BST)Copyright: Getty Images
Lucky number seven?
That's certainly what the Cincinnati Bengals and Miami Dolphins are hoping for.
Both sides are without a win as we enter week seven of 17.
The San Francisco 49ers, meanwhile, have a chance to go 6-0.
Stay tuned as we bring you all the action from around the NFL.Copyright: Getty Images