The best of Britain head to Birmingham's Alexander Stadium in the hopes of booking their spot at the World Championships in Doha.
Triple European champion Dina Asher-Smith is fresh off the back of a second-place finish in the 200m at the Birmingham Grand Prix but will contest the 100m where she will look to defend her title after clocking a Championship record on the way to victory in 2018.
In the men's equivalent, Zharnel Hughes is huge favourite to claim his first British 100m title.
Hughes' time of 9.95 seconds at the London Anniversary Games makes him the fastest man in the field, and he will seek to complete the sprint double by winning the 200m.
Laura Muir will miss out once again as the Scot continues to recover from an injury sustained at the London Anniversary Games in July.
Key events: 100m finals - women's 16:46 and men's 16:56