Thank you for joining us. Join Tom Rostance and Mike Henson's Premier League live text for the latest reaction from around the top flight.
It's all over. Frank Lampard ends his Premier League career in fairytale fashion, while Southampton's European hopes are out of their hands.
Into added time now. That was Aguero's 26th league goal of the season.
Southampton will have to wait to see if Aston Villa win the FA Cup to find out if they will be in the Europa League next season.
Sergio Aguero cements his status as Premier League top scorer with a simple finish. Jesus Navas's shot is deflected miles into the air, it loops over the head of Kelvin Davis and is nodded back across goal by Eliaqium Mangala for Aguero to head in.
Wilfried Bony lets fly with a rasping shot from 25 yards, but it's always rising over the bar.
It's just not happening for Southampton. Mane plays a neat one-two with Elia, but he fouls Zabaleta as he tries to scamper into the area.
And another player who could be making his final Manchester City appearance departs. James Milner, a man with huge question marks hanging over his future, is replaced by Vincent Kompany. Again he gets a huge ovation. Martin Demichelis steps into midfield.
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One of the great Premier League careers comes to an end. Frank Lampard embraces Manuel Pellegrini as he leaves the pitch for the final time as a Manchester City player. Jesus Navas replaces him.
Milner has gone off for a bit but Manchester City are holding off on making the change. Eljero Elia is on for Southampton.
Former Arsenal defender Martin Keown
"I think Pellegrini will be there next season. There will not be any panic but now the Financial Fair Play fine has been lifted, there will be spending this summer although I am a little bit disturbed that James Milner is going to be allowed to leave.
"This season they were just a little bit too complacent. I think this team have come to their end and they need a new breed of players."
James Milner has stayed down after a tackle by Shane Long and I'm not he's going to be able to continue here.
Oh, what a chance that is. Southampton's best opportunity of the match. Sadio Mane peels off Kolarov and has a free header eight yards out but he gets his timing wrong and can't get any power in the effort. You'd expect a man who scored a three-minute hat-trick last week to do better.
For once, Graziano Pelle is onside as he is released down the inside left by Sadio Mane's clever reverse pass but his cross is easily gathered by Joe Hart.
Jack Wright: The highest goalscorer and the most clean sheets; on that logic Manchester City should've dominated.
Kolarov whips in a great cross but Bony can't reach it.
Southampton have just been a little bit better in the last few minutes, but they still haven't really tested Joe Hart. Shane Long hits a side-footed effort from outside the area but it's tame.
Well well, could that be the last we see of Yaya Toure at the Etihad? He leaves the field to a standing ovation as Wilfried Bony enters the fray.
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Dear oh dear. Graziano Pelle has just been caught offside for the fourth time in about ten minutes. No sign of an equaliser for Saints at the moment.
Ronald Koeman makes his first change, as James Ward-Prowse is introduced in place of Filip Djuricic. Southampton need some inspiration from somewhere.
And another chance for Frank Lampard. Again it's Milner who picks him out, a floated cross to the back post, but Lampard can only nod it in to the arms of Kelvin Davis.
Here's some news to cheer Saints fans. Jay Rodriguez is in the Southampton travelling party for the first time in 13 months today - it was on this very ground that he suffered that dreadful injury last season. It will be great to see him back fit and firing next year.
Southampton are getting on the ball a bit more at the start of the second half, and their front line is certainly looking a bit more lively. Graziano Pelle sidefoots Steven Davis's cross against the post, but he was well offside.
A clean sheet today will give Joe Hart the Golden Glove award for the fourth time. Halfway there...
Ooh, that could have been two! Sergio Aguero cleverly feeds Frank Lampard on the edge of the area with a nifty backheel, but for once, the midfielder's control just lets him down.
Fittingly, Frank Lampard gets the ball rolling for his final half of Premier League football.
- Copyright: Getty Images
Manchester City manager Manuel Pellegrini paid tribute to goalscorer Frank Lampard in today's match programme.
He says: "He has only been here a season but he has already shown why he will be remembered as an all-time great. From the moment he arrived he set an example with his professionalism and he has scored some big goals for us too."
City fans, are you sorry to be seeing Frank go? Does he still have more to offer at the Etihad? Let us know on Twitter at #bbcfootball.
Well, all eyes were on Frank Lampard and he has delivered in style. His goal separates the sides at the break.
Suddenly, from nowhere, Southampton almost do have a leveller! Djuricic slips a nice ball between the centre-backs to Shane Long, and as the Irishman is tackled, the ball runs invitingly loose to Graziano Pelle, who whacks it wide. Decent chance.
Manchester City are winning the midfield battle, they are just quicker to everything in the middle of the park. Southampton don't look to have a response in them before the break.
Another great chance for Manchester City and a great save by Kelvin Davis. A powerful driving run by Yaya Toure sets up Sergio Aguero, Alderweireld comes across to make a good tackle but the ball rebounds off Aguero's foot and is heading for the top corner before Davis intervenes with an acrobatic stop.
A great cross from Sadio Mane finds Shane Long unmarked in the area but he can't control the shot. The linesman's flag goes up anyway.
Tim Arstall: I think Frank Lampard has used voodoo to steal Gerrard's fairytale ending.
- Copyright: Reuters
That's the fairytale scenario! Frank Lampard marks his final Premier League appearance with goal number 177, side-footing home James Milner's cut-back from 10 yards out. A very characteristic strike.
From Manchester City's third corner of the game, David Silva's low cross is deflected and Yaya Toure just misses it with an acrobatic effort. Pressure beginning to build on Southampton now.
Worth noting that Liverpool are two down at Stoke, so a Southampton goal here would take them sixth as it stands - good news for their Europa League qualification hopes.
Shane Long goes into the book for a cynical trip on James Milner.
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The opportunities are coming now for Man City. Kelvin Davis can't hold Yaya Toure's shot from the edge of the area and Sergio Aguero looks certain to convert the tap-in, but the keeper recovers well to smother the shot.
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Scrap that, this is the best chance we've seen. David Silva plays in Sergio Aguero with a beautifully weighted pass but the striker shows an uncharacteristic lack of composure, blazing over from a tight angle.
That's the best chance we've seen so far. Shane Long skips away from Pablo Zabaleta after an error from the right-back but his shot is weak and easily saved by Joe Hart.
Henry: Sobering moment when you realize legends like Lampard and Gerrard won't be back in the PL next season.
- Copyright: BBC Sport
How's this for a coincidence?
Aleksandar Kolarov has a mean cross on him usually but he gets this one all wrong, hitting the ball straight out of play. Hand up in apology. Pretty low-key start at the Etihad, to be honest.
Mangala gives away a free-kick for a clumsy challenge on Djuricic, but Jose Fonte can only get a glancing contact on Steven Davis's set-piece delivery and the chance is gone.
Patient build-up by Manchester City on the edge of the area eventually earns them a corner when James Milner is tackled on the byline. The set piece comes to nothing though as Toby Alderweireld gets down well to block Milner's low centre.
Sadio Mane chases after a long ball, but gives away a free-kick for a shove on Pablo Zabaleta. Unnecessary.
You didn't think he'd keep his cards in his pocket on his final Premier League appearance, did you? Chris Foy takes three minutes to make his mark, booking Martin Demichelis for a late challenge on Filip Djuricic.
Southampton win a corner inside the opening 30 seconds, but it's well headed away by the giant figure of Eliaquim Mangala.
It's also the Premier League swansong for referee Chris Foy, who is officiating his final top-flight match at the age of 52.
Bet he's hoping for a quiet afternoon.
A handshake for the departing Frank Lampard from one of the mascots in the tunnel. Nicely formal.
For Manchester City, by contrast, it's been a season of disappointment - they've failed to mount a convincing defence of their Premier League title.
They are almost guaranteed to finish the season as top scorers in the league for the third time in the last four seasons, but it's defensive weaknesses that have cost them dear.
Plenty of question marks hang over the Etihad today - we know Frank Lampard will be departing but could this also be a farewell appearance for Yaya Toure, James Milner or even Manuel Pellegrini?
If any team deserves to finish this Premier League on a high, it's surely Southampton, who have confounded expectations under Ronald Koeman this term.
Saints were tipped for relegation by many after losing five of their star players over the summer, including Luke Shaw and Adam Lallana, but they've bounced back superbly, thanks to an impressive defence superbly marshalled by Jose Fonte, allied to the goals of new recruits Sadio Mane and Graziano Pelle.
Can they upset the odds one last time this afternoon?
- Copyright: BBC Sport
As we mentioned, Frank Lampard captains Manchester City on his final Premier League appearance, as Manuel Pellegrini names the same side that beat Swansea last week.
Paulo Gazzaniga and James Ward-Prowse drop out of the Saints line-up, replaced by Kelvin Davis and Filip Djuricic.
Man City XI: Hart, Zabaleta, Demichelis, Mangala, Kolarov, Fernandinho, Milner, Lampard, Toure, Silva, Aguero.
Southampton XI: K. Davis, Clyne, Fonte, Alderweireld, Bertrand, Wanyama, S. Davis, Djuricic, Mané, Long, Pelle.
Hello and welcome to live text commentary of Manchester City v Southampton at the Etihad.
Manchester City are secure in second place but it could be an important final match for Ronald Koeman's visitors - if they can take something from this game, they will clinch a place in next season's Europa League.
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After 608 games, it's time to bid farewell to arguably the greatest midfielder of the Premier League era.
It's not the way Frank Lampard would have wanted to bow out, with little left to play for for Manchester City, but it will still be a proud moment as he takes the armband for Manuel Pellegrini's side.
Will he enjoy a victorious send-off? Well, Southampton will be determined to spoil the party, and with confidence high following a 6-1 thrashing of Aston Villa, they could well do just that.