Alexis Sanchez returns for Arsenal, replacing Theo Walcott. The Gunners' only other change sees Gabriel come in to the centre of defence for Per Mertersacker.
Arsenal XI: Cech, Bellerin, Gabriel, Koscielny, Monreal, Flamini, Ramsey, Campbell, Ozil, Sanchez, Giroud.
Southampton make two changes. Oriel Romeu and James Ward Prowse come in to midfield in place of Jordy Clasie and Matt Targett, both of whom are on the bench. There is no Charlie Austin in the 18 - he has got a 'slight knock'.
Southampton XI: Forster, Soares, Fonte, Van Dijk, Bertrand, Wanyama, Romeu, Mane, Ward-Prowse, Tadic, Long.